Povezanost dislipidemije i agresivnog ponašanja u shizofreniji

professional thesis

• Author: Ivona Bosanac
• Mentor: Miroslav Herceg (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Miroslav Herceg (član povjerenstva)
• Committee member: Vesna Bačić Vrca (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; Zagreb
• Defense date and country: 2020-03-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj ovog rada je pregledno prikazati povezanost lipida i agresivnog ponašanja u shizofreniji te
se osvrnuti na važnost kvalitetne ljekarničke skrbi prema agresivnom bolesniku, kako bi se
spriječili neželjeni ishodi i omogućila sigurna i učinkovita psihofarmakoterapija.
U tu svrhu pretražena je znanstvena i stručna literatura, publikacije stručnih institucija,
relevantni psihijatrijski dijagnostički priručnici, važeće terapijske i dijagnostičke smjernice te
drugi raspoloživi izvori.
Identificirane su moguće poveznice između lipida i agresivnog ponašanja u shizofreniji te
specifična stanja i situacije koje utječu na tu vezu poput: velike učestalosti metaboličkog
sindroma u shizofreniji, sklonosti agresivnom ponašanju bolesnika oboljelih od shizofrenije i
liječenja antipsihoticima. Da je ovo vrlo kompleksna tema, govori i to što je teško razlučiti je li
primjerice dislipidemija u podlozi shizofrenije ili je samo nuspojava liječenja antipsihoticima.
Opisana je važnost kolesterola i drugih lipida u razvoju agresivnog ponašanja te je istaknuta
uloga serotonina kao glavnog medijatora između lipida i agresivnosti. Također je napravljen i
osvrt na potencijalne markere agresivnog ponašanja u shizofreniji temeljem lipidnog profila
oboljelih.
Povezanost lipida i agresivnog ponašanja u shizofreniji sve više dobiva na važnosti te se
intenzivno razmatra screening i praćenje bolesnika oboljelih od shizofrenije za koje bi se
temeljem lipidnog profila moglo zaključiti da su u većem riziku od nasilnog, agresivnog
ponašanja koje bi u konačnici imalo negativne posljedice za pojedinca ili društvo.

Abstract (english)

The aim of this paper is to do a review of association between lipids and aggressive behaviour
in schizophrenia, as well as to give an end view on the role of the pharmaceutical care for
aggressive patients in order to prevent adverse outcomes and to enable safe and effective
psychopharmacotherapy.
For this purpose, relevant scientific and professional literature, publications of professional
institutions, relevant psychiatric diagnostic manuals, currently relevant treatment and
diagnostic guidelines and other available resources were searched.
Possible links between lipids and aggressiveness in schizophrenia were identified, as well as
specific conditions that can influence on this association like: high prevalence of metabolic
syndrome in schizophrenia, tendency to aggressiveness of patients who have schizophrenia and
treatment with antipsychotics. It is actually very hard to understand is for example dyslipidemia
in the base of schizophrenia, or is it only adverse effect of treatment with antipsychotics. There
has been described the role of cholesterol and other lipids in development of aggressive
behaviour and pointed out the role of serotonin as main mediator between lipids and
aggressiveness in schizophrenia. Also there has been given an end view on potential markers
of aggressive behaviour in schizophrenia based on lipid profiles of those who suffer from
schizophrenia.
Association between lipids and aggressive behavior is becoming more important and there are
serious considerations that screening of patients who have schizophrenia based on their lipid
profiles could identify the risk of violent, aggressive behaviour that could have negative impact
on individual or society.

• Keywords: agresivno ponašanje; dislipidemija; kolesterol; lipidi; serotonin; shizofrenija
• Keywords (english): aggressive behaviour; dyslipidemia; cholesterol; lipids; serotonin; schizophrenia
• Language: croatian
• URN:NBN: urn:nbn:hr:163:173161
• Study programme: Title: Clinical pharmacy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/sveučilišna magistra kliničke farmacije (sveučilišni/a magistar/sveučilišna magistra kliničke farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-03-30 14:09:19