Etilenglikol i dietilenglikol u zubnim pastama na hrvatskom tržištu

Scientific paper - Original scientific paper

• Author: Ivona Vidić Štrac
• Author: Irena Žuntar
• Author: Nino Dimitrov
• Author: Maja Puklek
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Diethylene glycol (DEG) (CAS 111-46-6) is a highly
toxic organic solvent that may cause nausea, dizziness, kidney failure, breathing
problems, convulsions and even coma when ingested The potential health
risks from chronic exposure to DEG are a particular concern in specific
vulnerable populations such as children and consumers with kidney or liver
disease. DEG is forbidden as cosmetic ingredient but can be present as an
impurity in glycerol and polyethylene glycols, common ingredients in oral
care products. Maximum permitted concentration as impurity is 0.1 % m/m.
the objective of this study was to determine the presence of diethylene glycol
in toothpaste on the Croatian market using a gas chromatography-mass
spectrometry method. Linearity of the response of mass detector was tested by
analyzing standard solutions with increasing concentrations of ethylene glycol
(EG) and diethylene glycol. Regression analysis of chromatographic data
indicates that linearity of response in the detector was within the examined
concentration area 0.5-50 mg/L, with correlation coefficients >0.998. Limit
of detection (LOD) far DEG was < 6 mg/kg, and far EG < 4 mg/kg. Testing
was conducted on 30 samples of toothpaste produced and marketed in Croatia
and EU. Obtained results were significantly below the permitted threshold
of 0.1 % thus assuring consumer safety.

• Keywords (croatian): etilenglikol; dietilenglikol; zubne paste; otrovanje
• Language: croatian
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 69, no. 5, pp. 319-331
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:834051
• Publication: 2013
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-07-07 13:34:33