Potencijali i izazovi izrade magistralnih pripravaka za pedijatrijsku populaciju

professional thesis

• Author: Jelica Liščić
• Mentor: Jelena Filipović-Grčić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Jelena Filipović-Grčić (član povjerenstva)
• Committee member: Maja Lusina Kregar (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2022-11-23, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Magistralni pripravci su od velikog značaja u učinkovitoj personaliziranoj terapiji. Izrađuju se
ukoliko se liječenje ne može provesti s odobrenim komercijalno dostupnim lijekom (gotovi lijek).
Razlozi za to mogu biti brojni, a najčešće je to prilagodba doze zbog toga što gotovi lijek nije
dostupan u adekvatnoj dozi s obzirom na dob i stanje bolesnika, potom prilagodba formulacije u
slučaju bolesnika alergičnih ili osjetljivih na pojedine pomoćne tvari gotovog lijeka, bolesnika na
enteralnoj prehrani te bolesnika koji pate od teške disfagije.
Potreba za izradom magistralnih pripravaka posebno je izražena u pedijatriji.
S obzirom da se radi o posebno osjetljivoj skupini bolesnika, cilj ovog rada je, kroz primjere iz
ljekarničke prakse, ukazati na potencijale i izazove izrade učinkovitih, sigurnih i stabilnih
pedijatrijskih magistralnih pripravaka u obliku suspenzija, podijeljenih prašaka i kapsula.

Abstract (english)

Magistral formulations are of great importance for effective personalized therapy. They are often
prepared and used when treatment cannot be given with a commercially available drug, because
the drug is not available at an adequate dose (depending on the age of the patient), or when the
drug formulation is not suitable for use in patients requiring dose adjustment, or when the patient
is sensitive to certain excipients in the commercial drug, as well as in patients who are fed
enterally nutrition, and in patients suffering from severe dysphagia.
The need for the use of magistral formulations is particularly pronounced in the pediatric
population.
Since children are particularly sensitive group of patients, the aim of this study is to present
examples from pharmacy practice to highlight the opportunities and challenges in the
manufacture of pediatric magistral formulations in the form of suspensions, divided powders and
capsules, and to highlight their shortcomings in terms of manufacture and quality.

• Keywords: magistralni pripravci; pedijatrijski pripravci; pedijatrija
• Keywords (english): magistral formulations; pediatric formulations; pediatrics
• Language: croatian
• URN:NBN: urn:nbn:hr:163:881104
• Study programme: Title: Drug development; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra razvoja lijekova (sveučilišni magistar/sveučilišna magistra razvoja lijekova)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-09 15:54:37