Analiza troška i učinka oralnih hitnih kontraceptiva

master's thesis

• Title (english): Cost-effectiveness analysis of oral emergency contraception
• Author: Maja Gržančić
• Mentor: Petra Turčić (mentor)
• Committee member: Petra Turčić (predsjednik povjerenstva)
• Committee member: Lada Rumora (član povjerenstva)
• Committee member: Marija Grdić Rajković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2016-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Oralna hitna kontracepcija predstavlja veliki napredak za društvo, osobito žene u pogledu
planiranja obitelji. Danas su u Hrvatskoj registrirana dva preparata za oralnu hitnu kontracepciju:
preparat s levonorgestrelom (sintetski gestagen) i ne-hormonalni preparat s ulipristal acetatom
(selektivni modulator progesteronskih receptora). Oba su u bezreceptnom režimu izdavanja jer je
procjenjeno da je omjer koristi i rizika pozitivan. Prema pregnancy rate, oba preparata imaju
podjednaku djelotvornost unutar 72 sata, dok je u perioiodu između 72 i 120h s obzirom na
djelotvornost u prednosti ulipristal acetat. Logika nalaže da je prebacivanje hitne oralne
kontracepcije iz receptnog u bezreceptni režim donijelo uštede zdravstvenom sustavu. Veća
dostupnost je omogućila pravovremeni pristup pacijentice lijeku (osobito ženama koje nemaju
ginekologa te u vrijeme blagdana i vikenda) te je povećan broj sprječenih neželjenih trudnoća.
Oralni hitni kontraceptivi imaju pozitivan omjer cijene i učinka neovisno o tome nabavi li se kad
se pojavi potreba ili preventivno. Učinak je vidljiv u medicinskim i socijalnim uštedama uslijed
izbjegavanja neželjene trudnoće, a nije zanemariv ni pozitivan psihološki učinak.

Abstract (english)

Oral emergency contraception is a major plus for society, especially women in terms of family
planning. Today in Croatia there are two registered products for oral emergency contraception:
preparation with levonorgestrel (a synthetic progestogen) and non-hormonal preparation with
ulipristal acetate (selective progesterone receptor modulator). Both are in OTC mode of issue
because it is estimated that the benefit-risk ratio is positive. According to pregnancy rate, both
products have similar effectiveness within 72 hours, between 72 and 120h ulipristal acetate has the
advantage. Logic dictates that the transfer of emergency oral contraception from prescription to
OTC regime brought savings to the health care system. The increased availability allowed timely
access to the drug (especially to women who do not have a gynecologist and during the holidays
and weekends) and decreased the number of unwanted pregnancies. Emergency oral contraception
has a positive cost-effectiveness ratio regardless if it is obtained when the need arises or as a
prevention. The effect is visible in the medical and social savings due to avoidance of unwanted
pregnancies and there is a significant positive psychological effect.

• Keywords: hitna kontracepcija; ulipristal-acetat; levonorgestrel; farmakoekonomika; farmakoekonomska analiza
• Keywords (english): emergency contraception; ulipristal-acetate; levonorgestrel; pharmacoeconomics; pharmacoeconomical analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:608534
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-12-02 10:03:43