Nanokristali s biološki aktivnim tvarima u dermalnoj primjeni

master's thesis

• Title (english): Nanocrystals with biological active ingredients in dermal application
• Author: Danijela Babić
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Jasmina Lovrić (član povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2018-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Nanokristali djelatne tvari pripadaju skupini suvremenih terapijskih nanosustava kojima se nastoje poboljšati farmaceutsko-tehnološka i/ili biofarmaceutska svojstva biološki aktivne tvari. Obzirom na izradu nanokristala farmaceutsko-tehnološke metode moguće je podijeliti u dvije glavne skupine: (i) metode smanjenja veliĉine ĉestica (engl. top-down methods) i (ii) metode povećanja veliĉine ĉestica (engl. bottom-up methods). Osnovni cilj ovog diplomskog rada bio je prouĉiti znanstvenu literaturu i pregledno izdvojiti najnovije informacije vezane uz tehnologiju izrade nanokristala i njihovu dermalnu primjenu. Uĉinkovitost dermalne primjene ovisi o sloţenom meĊuodnosu znaĉajki biološki aktivne tvari, podloge i koţe. Fiziĉko-kemijske znaĉajke biološki aktivnih tvari vrlo ĉesto ograniĉavaju njihovu primjenu. Primjenom tehnologije nanokristala moguće je osigurati bolju uĉinkovitost slabo topljivih biološki aktivnih tvari nakon dermalne primjene. Zahvaljujući povećanoj topljivosti, povećanoj brzini otapanja i posljediĉno povećanoj adhezivnosti farmaceutski oblik s uklopljenim nanokristalima pokazuje poboljšanu dermalnu bioraspoloţivost u odnosu na konvencionalne pripravke. Daljnji razvoj i primjena tehnologije nanokristala biološki aktivnih tvari zasigurno će pridonijeti uĉinkovitijem i sigurnijem lijeĉenju razliĉitih oboljenja koţe.

Abstract (english)

Drug nanocrystals belong to a group of modern therapeutic nanosystems seeking to improve pharmaceutical and/or biopharmaceutical properties of biologically active ingredients. Pharmaceutical-technological methods can be divided into two main groups, according to the type of development of drug nanocrystals: (i) top-down methods and (ii) bottom-up methods. The main aim of this diploma thesis was to study scientific literature and abstract the latest information on nanocrystal technology and dermal application of nanocrystals. The efficacy of dermal application depends on the complex interrelationship of the properties of biologically active ingredients, substrates properties and skin properties. The physicochemical properties of biologically active ingredients often limit their application. By using nanocrystal technology, it is possible to provide better efficacy of poorly soluble biologically active ingredients after their dermal application. Due to increased saturation solubility, increased dissolution velocity and, consequently, increased adhesiveness, pharmaceutical form with embedded nanocrystals shows improved dermal bioavailability, compared to the conventional formulations. Further development and application of nanocrystal technology of biologically active ingredients will certainly contribute to more effective and safer treatment of various skin diseases.

• Keywords: nanokristali; biološki aktivne tvari; dermalna primjena
• Keywords (english): nanocrystals; biological active ingredients; dermal application
• Language: croatian
• URN:NBN: urn:nbn:hr:163:341473
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-04-12 08:39:13