Potencijalno neprikladni lijekovi u osoba starije životne dobi utvrđeni STOPP i Beers kriterijima

master's thesis

• Title (english): Detection of potentially inappropriate medications in elderly patients using STOPP and Beers criteria
• Author: Maja Milinović
• Mentor: Vesna Bačić Vrca (mentor)
• Committee member: Vesna Bačić Vrca (predsjednik povjerenstva)
• Committee member: Jelena Filipović-Grčić (član povjerenstva)
• Committee member: Maja Ortner Hadžiabdić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2019-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja bio je odrediti učestalost propisivanja potencijalno neprikladnih lijekova u
bolesnika starije životne dobi prije i nakon otpusta iz bolnice koristeći Beersove kriterije i
STOPP kriterije. U presječno opservacijsko istraživanje provedeno u Kliničkoj bolnici Dubrava
bili su uključeni akutno i elektivno hospitalizirani bolesnici u dobi od 65 i više godina koji su
uzimali jedan ili više lijekova i koji su potpisali pristanak za sudjelovanje u istraživanju.
Potencijalno neprikladni lijekovi bili su određeni pomoću dva različita protokola: Beers kriterija
i STOPP kriterija. Ukupno je bilo uključeno 180 bolesnika prosječne dobi 75,0godina (raspon
65- 96), koji su u prosjeku trošili 6,1 lijekova (raspon 1-19) te imali 7,8 dijagnoze (raspon 0- 15).
Beers kriteriji otkrili su ukupno 352 PNL-a(24,9%) u terapiji prijema propisanih 150 (83,3%)
ispitanika, dok je u terapiji otpusta potencijalno neprikladnih lijekova bilo nešto manje, ukupno
310(21,9%) koji su propisani 133 (73,9%) ispitanika. Pomoću STOPP kriterija otkriveno je 175
(12,4%) potencijalno neprikladna lijeka koji su bili propisani 107 (59,4%) ispitanika u terapiji
prije prijema, dok su u terapiji na otpustu otkrivena 155 (10,9%) potencijalno neprikladna lijeka
propisana 102 (56,7%) bolesnika. Beers kriteriji su se pokazali učinkovitijim u otkrivanju
PNL.Ukupan broj PNL kod prijema bio je veći u odnosu na broj PNL kod otpusta (Beers: 352vs
310; STOPP: 175 vs 155). Najčešće propisivani potencijalno neprikladan lijek prema oba
protokola bio je diazepam, a ostali su acetilsalicilna kiselina, pantoprazol, furosemid, ibuprofen i
bisoprolol. Korištenjem protokola za detekciju PNL-a može se postići se racionalnije
propisivanje lijekova, poboljšati kvaliteta života i smanjiti ukupni troškovi liječenja.

Abstract (english)

The aim of this study was to determine prevalence of prescribing potentially inappropriate
medications (PIMs) in elderly patients before and after hospitalization. Beers and STOPP criteria
were used to detect potentially inappropriate medications. A cross-sectional observational study
was conducted in University Hospital Dubrava. We included acutelly and electively admitted
inpatients aged 65 years and older who were taking one or more drugs and who had signed
consent to participate in research. PIMs were determined using two different protocols: Beer’s
criteria and STOPP criteria. The study included 180 patients with a median age 75,0 years (range
65-96). On average, the patients spent 6,1 medications (range 1-19) and had a diagnosis of 7,8
(range 0-15). The Beers criteria detected 352(24,9%) of PIMs before hospitalization that were
prescribed to 150 (83,3%) patients while after the hospitalization there were slightly fewer
medications, in total 310(21,9%) that were prescribed to 133 (73,9%) patients. The STOPP criteria
detected 175 (12,4%) of PIMs before hospitalization that were prescribed to 107 (59,4%) patients
while after the hospitalization there was 155 (10,9%) of PIMs that were prescribed to 102 (56,7%)
patients. A Beers criteria proved to be better tool in the detection of PIMs.The total number of
PNLs before the hospitalziation is higher than the number of PNLs at release (Beers: 352 vs 310;
STOPP: 175 vs 155) According to both protocols, the most prevalent inappropriate drug was
diazepam, and the rest of them were acetylsalicylic acid, pantprazole, furosemide, ibuprofen and
bisoprolol.Using different protocols in detecting potentially inappropriate medications causes
more rational prescribing, improves life quality and reduces the overall cost of treatment.

• Keywords: starije osobe; potencijalno neprikladni lijekovi; Beers kriteriji; STOPP kriteriji
• Keywords (english): elderly; potentially inappropriate medications; Beers criteria; STOPP criteria
• Language: croatian
• URN:NBN: urn:nbn:hr:163:595911
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-02-18 16:45:16