Liposomi u liječenju sideropenične anemije

master's thesis

• Title (english): Liposomes for the treatment of iron deficiency anemia
• Author: Ana Baburić
• Mentor: Željka Vanić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Roberta Petlevski (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2019-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Deficit željeza najčešći je nutricijski poremećaj u svijetu, koji posljedično dovodi do razvoja
sideropenične anemije. Procjenjuje se da oko 25% ukupne populacije boluje od sideropenične anemije,
a najrizičnije skupine su predškolska djeca i žene reproduktivne dobi. Uobičajena terapija sideropenične
anemije može biti peroralna ili parenteralna, ali oba tipa primjene imaju visoku incidenciju nuspojava i
time nisku stopu suradljivosti pacijenata. S obzirom na to, pokušavaju se pronaći nove terapijske
mogućnosti prevencije i liječenja deficita željeza i sideropenične anemije, a jedna od njih je i primjena
peroralnih suplemenata liposomskog željeza. Uklapanje željeza u liposome rezultiralo je boljom
apsorpcijom, postupnim oslobađanjem željeza i smanjenom incidencijom nuspojava budući da je
izbjegnut direktan kontakt željeza s gastrointestinalnom sluznicom. Ovaj rad donosi pregled primjene
istraživanja i kliničke primjene liposomskog željeza u peroralnoj terapiji prevencije i liječenja deficita
željeza i sideropenične anemije.

Abstract (english)

Iron deficiency is one of the most frequent health problems in the world which leads to iron
deficiency anemia. It is estimated that up to one third of the global population is affected. Iron
deficiency anemia is usually treated either with oral iron salts or intravenous iron formulations
but there is a high risk of side effects leading to reduced treatment compliance. The use of
liposomes as carriers represents innovative oral iron therapy which improves iron
bioavailability, enables iron to be gradually released and reduces negative effects. This thesis
provides an overview of research and clinical use of liposomal iron formulations as oral therapy
in prevention and treatment of iron deficiency and anemia.

• Keywords: liposomi; željezo; anemija; oralna primjena; klinička primjena; Sukrosomialno® željezo
• Keywords (english): liposomes; iron; anemia; oral drug formulations; clinical use; Sucrosomial®iron
• Language: croatian
• URN:NBN: urn:nbn:hr:163:400355
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-02-24 08:55:08