Priprava i karakterizacija emolijentnoga gela za pranje i emulzije za njegu kože osoba s atopijskim dermatitisom

professional thesis

• Author: Maja Vugrinec
• Mentor: Jelena Filipović-Grčić (mentor)
• Committee member: Jelena Filipović-Grčić (predsjednik povjerenstva)
• Committee member: Ivan Pepić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2020, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

CILJ ISTRAŽIVANJA: Cilj ovog istraživanja je razviti formulaciju emolijentnoga gela za pranje i emulzije
za njegu kože osoba s atopijskim dermatitisom, koji bi sa svojim prirodnim sastavnicama potpomogli
terapiji ove bolesti.
MATERIJAL/ ISPITANICI I METODE: Nakon razvoja formulacija, ispitana je njihova djelotvornost na
koži obraza osoba s atopijskim dermatitisom u Gradskoj ljekarni Zagreb OJ 13, u Kamenitoj ulici 9 u
Zagrebu, pomodu uređaja za analizu kože Multi Skin Test Center MC 1000 i Visiosope kamere
("Courage+Khazaka", Köln, Njemačka) sa sondama koje mjere transepidermalni gubitak vode (TEWLmetar)
i hidrataciju kože (korneometar). Ispitivanje je trajalo 24 sata, a provedeno je na ukupno 10
ispitanika s dijagnozom atopijskog dermatitisa. Parametri transepidermalni gubitak vode i hidratacija
izmjereni su na koži oba obraza ispitanika neposredno prije i 24 sata nakon primjene formulacija.
Formulacije su primijenjene na jednom obrazu, a drugi obraz je služio kao kontrola.
REZULTATI: Rezultati ovog ispitivanja pokazali su smanjeni transepidermalni gubitak vode i povedanu
hidrataciju epidermisa, odnosno poboljšanje epidermalne zaštitne barijere kože nakon primjene
formulacija.
ZAKLJUČAK: Pravilnom njegom kože mogude je ublažiti glavne simptome atopijskog dermatitisa kao
što su suhoda, iritacija, svrbež, upala i infekcija.

Abstract (english)

OBJECTIVES: The aim of this research is to develop a formulation for emollient shower gel and
emulsion for people with atopic dermatitis that would improve the treatmentof this disease with
their natural components.
MATERIAL/PATIENTS AND METHODS: After the development of formulations, their effectiveness was
evaluated on the cheek of patients with atopic dermatitis in Zagreb City Pharmacy, in Kamenita
Street 9 in Zagreb, using a skin tester Multi Skin Test Center MC 1000 and Visiosope Camera
(Courage + Khazaka, Köln , Germany) with probes that measure transepidermal water loss (TEWLmeter)
and skin hydration (corneometers). The research lasted for 24 hours and included ten atopic
dermatitis diagnosed patients. The transepidermal water loss and hydration parameters were
measured on the skin of both cheeks just before and 24 hours after the application of the
formulations. The formulations were applied on one cheek, while the other served as control.
RESULTS: The results of this study showed reduced transepidermal water loss, increased epidermal
hydration and improved epidermal skin barrier protection after the application of these
formulations.
CONCLUSION: Proper skin care can relieve the main symptoms of atopic dermatitis such as dryness,
irritation, itching, inflammation and infection.

• Keywords: atopijski dermatitis; emolijentni gel za pranje; emulzija
• Keywords (english): atopic dermatitis; emollient shower gel; emulsion
• Language: croatian
• URN:NBN: urn:nbn:hr:163:716192
• Study programme: Title: Dermopharmacy and cosmetology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-03-05 15:00:18