Suplementacija s antioksidansima i serumski lipidi kod bolesnika s Graves-ovom bolesti: Učinak na LDL-kolesterol

Scientific paper - Preliminary note / Short communication

• Title (english): Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol
• Author: Vesna Bačić Vrca
• Author: LJiljana Mayer
• Author: Franjo Škreb
• Author: Dario Rahelić
• Author: Srećko Marušić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

U ovom istraživanju promatran je učinak suplementacije fiksnom kombinacijom antioksidansa (beta-karoten, selen, vitamin C i E) na koncentracije serumskih lipida, u odnosu na brzinu postizanja eutiroze. Mjerenja su obavljena u bolesnika s novo otkrivenom Graves-ovom bolešću liječenih metimazolom (tiamazolom) prije početka terapije, te nakon 30 i 60 dana. Bolesnici su bili randomizirani u dvije skupine. Test skupinu sačinjavali su bolesnici koji su dodatno uzimali antioksidanse, a kontrolnu skupinu bolesnici koji su uzimali samo metimazol (tiamazol). Koncentracije ukupnog i HDL-kolesterola u serumu rasle su tijekom terapije kod bolesnika iz obje skupine (p < 0,05) no, nisu se međusobno značajno razlikovale 60 dana nakon početka terapije. Kod bolesnika test skupine, koncentracija LDL-kolesterola se značajno povećala (p < 0,005) i bila je značajno različita od one u kontrolnoj skupini (p < 0,005), 60 dana nakon početka liječenja.
Rezultati ovog istraživanja ukazuju da suplementacija s ovom kombinacijom antioksidansa nema značajnog utjecaja na promjene koncentracije serumskih lipida kod bolesnika s Graves-ovom bolešću 60 dana nakon početka terapije, s izuzetkom LDL-kolesterola. Zbog značajnog porasta koncentracije LDL-kolesterola kod bolesnika s Graves-ovom bolešću, koji su dodatno uzimali antioksidanse, potrebna su daljnja istraživanja u cilju pojašnjenja opisanih promjena.

Abstract (english)

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencing the therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.

• Keywords (croatian): Graves-ova bolest; antioksidansi; serumski lipidi; LDL-kolesterol
• Keywords (english): Graves' disease; antioxidants; serum lipids; LDL-cholesterol
• Language: croatian
• Language: english
• Publication type: Scientific paper - Preliminary note / Short communication
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 62, no. 1, pp. 115-122
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• DOI: https://doi.org/10.2478/v10007-012-0005-2
• URN:NBN: urn:nbn:hr:163:019181
• Publication: 2012
• Document URL: https://hrcak.srce.hr/76599
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-08 13:51:29