Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova

Scientific paper - Original scientific paper

• Title (english): Glycoscience - a new frontier in rational drug design
• Author: Olga Gornik
• Author: Jerka Dumić
• Author: Mirna Floegel
• Author: Gordan Lauc
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of biochemistry and molecular biology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (croatian)

Glikani su najrasprostranjeniji i najraznolikiji biopolimeri prisutni u prirodi. Zbog svojih interakcija s fiziološkim receptorima sudjeluju u mnogim ključnim biološkim procesima. Svi ti procesi potencijalna su meta terapeutskih intervencija pa lijekovi bazirani na ugljikohidratima nalaze svoje mjesto u suvremenoj biotehnologiji i farmaceutskoj industriji. Razvojem glikobiologije prevladan je problem sinteze i analize glikana pa su mnogi spojevi bazirani na ugljikohidratnim strukturama trenutno u različitim fazama kliničkih ispitivanja. Ovaj članak predstavlja glikoproteine u novom svjetlu, kao važne biofarmaceutske ciljeve, dajući pregled njihove potencijalne primjene kao terapijskih glikoproteina i proteoglikana, inhibitora upale, lijekova i vakcina u liječenju tumora, inhibitora patogenih mikroorganizama i virusa, te potencijalnih sredstava u liječenju lizosomskih i neuroloških bolesti te transplantacijskih reakcija.

Abstract (english)

Glycans are the most abundant and most diverse biopolymers in nature. Because of their highly specific interactions with physiological receptors, they participate in many crucial biological processes. All these processes are potential targets for therapeutic intervention, and carbohydrate-based drugs are rapidly being taken up by the modern biotechnology and pharmaceutical industry. Recent developments in the field of glycobiology have overcome the problem of glycan analysis and synthesis; and many compounds based on carbohydrates are now in various stages of clinical trials. This article presents glycoproteins in a new light, as an important biopharmaceutical target, giving an overview of their potential use as therapeutic glycoproteins and proteoglycans, inflammation blockers, cancer therapeutics and vaccines, inhibitors of pathogenic microbes, viral inhibitors and potential aids in the treatment of lysosomal diseases, neurological diseases and transplantation rejection.

• Keywords (croatian): glikoproteini; lektini; terapeutici
• Keywords (english): glycoproteins; lectins; therapeutics
• Language: croatian
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 56, no. 1, pp. 19-30
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• URN:NBN: urn:nbn:hr:163:540038
• Publication: 2006
• Document URL: https://hrcak.srce.hr/4562
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-08 14:27:40