Antimikrobna aktivnost flavonoida Pelargonium radula (Cav.) L’Hérit

Scientific paper - Preliminary note / Short communication

• Title (english): Antimicrobial activity of flavonoids from Pelargonium radula (Cav.) L’Hérit
• Author: Stjepan Pepeljnjak
• Author: Zdenka Kalođera
• Author: Marijana Zovko
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

Flavonoidi biljne vrste Pelargonium radula (Cav.) L’Hérit pročišćeni su kromatografijom na stupcu. Dobivene su dvije glavne flavonoidne frakcije: F1 (vodeći flavonoid izokvercitrin) i F2 (vodeći flavonoid rutin). Dilucijskom i difuzijskom metodom određena je antimikrobna aktivnost F1 i F2 na jedanaest bakterijskih sojeva i jedanaest sojeva gljivica. Obje frakcije pokazale su snažno inhibicijsko djelovanje na sojeve Staphylococcus aureus, Proteus rettgeri, Candida tropicalis i Microsporum gypseum. Na sojeve Staphylococcus sp. (koagulaza-negativan) i Candida lusitaniae snažno je djelovala samo frakcija F1, a na Fusarium graminearum samo frakcija F2.

Abstract (english)

Flavonoids from Pelargonium radula (Cav.) L'Hérit were purified by column chromatography. Two fractions were obtained: F1 (main flavonoid isoquercitrin) and F2 (main flavonoid rutin). In vitro antimicrobial activity of F1 and F2 were tested against eleven species of bacteria and eleven species of fungi. Both fractions demonstrated strong inhibitory activity against Staphylococcus aureus, Proteus rettgeri, Candida tropicalis and Microsporum gypseum. Staphylococcus sp. (coagulase-negative) and Candida lusitaniae were strongly inhibited only by fraction F1 and Fusarium graminearum only by fraction F2.

• Keywords (croatian): Pelargonium radula; antimikrobna aktivnost; flavonoidi; rutin; izokvercitrin; metoda difuzije; metoda dilucije
• Keywords (english): Pelargonium radula; antimicrobial activity; flavonoids; rutin; isoquercitrin; well-diffusion method; dilution method
• Language: croatian
• Language: english
• Publication type: Scientific paper - Preliminary note / Short communication
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 55, no. 4, pp. 431-435
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• URN:NBN: urn:nbn:hr:163:970390
• Publication: 2005
• Document URL: https://hrcak.srce.hr/19049
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-08 16:50:35