Lipofilnost salicilamida

Medić-Šarić, Marica; Mornar, Ana; Jasprica, Ivona

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Scientific paper - Original scientific paper

Lipofilnost salicilamida

Acta Pharmaceutica, 54 (2004), 2; 91-101. urn:nbn:hr:163:408547

Medić-Šarić, Marica; Mornar, Ana; Jasprica, Ivona

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APA 6th Edition

Medić Šarić, M., Mornar, A. & Jasprica, I. (2004). Lipofilnost salicilamida. Acta Pharmaceutica, 54. (2), 91-101. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:408547

MLA 8th Edition

Medić Šarić, Marica, et al. "Lipofilnost salicilamida." Acta Pharmaceutica, vol. 54, no. 2, 2004, pp. 91-101. https://urn.nsk.hr/urn:nbn:hr:163:408547

Chicago 17th Edition

Medić Šarić, Marica, Ana Mornar and Ivona Jasprica. "Lipofilnost salicilamida." Acta Pharmaceutica 54, no. 2 (2004): 91-101. https://urn.nsk.hr/urn:nbn:hr:163:408547

Harvard

Medić Šarić, M., Mornar, A. and Jasprica, I. (2004) 'Lipofilnost salicilamida', Acta Pharmaceutica, 54(2), pp. 91-101. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547 (Accessed 21 April 2024)

Vancouver

Medić Šarić M, Mornar A, Jasprica I. Lipofilnost salicilamida. Acta Pharmaceutica [Internet]. 2004 [cited 2024 April 21];54(2):91-101. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547

IEEE

M. Medić Šarić, A. Mornar and I. Jasprica, "Lipofilnost salicilamida", Acta Pharmaceutica, vol. 54, no. 2, pp. 91-101, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547. [Accessed: 21 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:408547

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Metadata

Title (croatian)	Lipofilnost salicilamida
Title (english)	Lipophilicity study of salicylamide
Author	Marica Medić-Šarić
Author	Ana Mornar
Author	Ivona Jasprica
Author's institution	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of medicinal chemistry)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract (croatian)	U radu je dan pregled istraživanja molekularne lipofilnosti na primjeru salicamida. Log P vrijednost određena je eksperimentalnom («shake-flash») metodom i izračunata je pomoću devet različitih računalnih programa koji se temelje na atom/fragmentarnoj metodi, strukturnim parametrima, atom elektrotopologijskim indeksima uz modeliranje putem neuronskih mreža i topologijskim deskriptorima. Statistička obrada dobivenih rezultata pokazala je najbolju korelaciju eksperimentalno dobivene vrijednosti s log P vrijednošću dobivenom računalnim programoma CslogP, koji se temelji na topologijskim deskriptorima i elektrotopologijskim indeksima.
Abstract (english)	Molecular lipophilicity was studied using salicylamide as a model drug. Log P value for the target compound was experimentally determined by the "shake-flask" method and calculated using nine different computer programs based on atom/fragment contributions, structural parameters, atom-type electrotopological-state indices and neural network modeling, and on topological structure descriptors. Our analysis demonstrates good agreement between the experimentally observed log P value of salicylamide and the value calculated by the CSLogP program, based on topological structure descriptors and electrotopological indices.
Keywords (croatian)
Keywords (english)
Language	croatian
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Acta Pharmaceutica
Numbering	vol. 54, no. 2, pp. 91-101
p-ISSN	1330-0075
e-ISSN	1846-9558
URN:NBN	urn:nbn:hr:163:408547
Publication	2004
Document URL	https://hrcak.srce.hr/16795
Type of resource	Text
Access conditions	Open access
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Created on	2020-04-09 13:41:00