Novel 57 kDa glycoprotein in the sera of humans under stress

Scientific paper - Original scientific paper

• Author: Mirna Flögel
• Author: Gordan Lauc
• Author: Tihana Žanić-Grubišić
• Author: Jerka Dumić
• Author: Karmela Barišić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of biochemistry and molecular biology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (english)

Serum glycoproteins from individuals under chronic stress (prisoners of war from detention camps, n - 30) were analyzed by the Western-blot method applying a set of five different lectins (DSA,
GNA, MAA, PNA and SNA). Glycoprotein patterns of samples from the stressed group revealed significant changes if compared to the control sera (from apparently non-stressed volunteers): both galactose-specific DSA lectin and sialic acid-specific SNA lectin recognized a novel nonconsitutional glycoprotein with an apparent size of 57 kDa in the stress group, which was completely absent in the control group. In addition, concentration of a 45 kDa SNA reactive glycoprotein increased more than 500 fold. The high incidence of disturbed patterns of glycoproteins in the sera of stressed subjects (95%) points to their important role in stress response and qualifies them for widespread testing as potential diagnostic markers of the stress syndrome.

• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 69, no. 1, pp. 371-378
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:017530
• Publication: 1996
• Document URL: https://hrcak.srce.hr/135969
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-04-29 14:11:35