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Scientific paper - Original scientific paper
The synthesis of some B6 vitamin halophosphates
Croatica Chemica Acta, 64 (1991), 2; 161-171. urn:nbn:hr:163:396693
Elshani, S.; Butula, Lj.; Butula, I.; Vikić-Topić, D.; Berton, A.; Iriarte, A.

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Elshani, S., Butula, Lj., Butula, I., Vikić Topić, D., Berton, A. & Iriarte, A. (1991). The synthesis of some B6 vitamin halophosphates. Croatica Chemica Acta, 64. (2), 161-171. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:396693

Elshani, S., et al. "The synthesis of some B6 vitamin halophosphates." Croatica Chemica Acta, vol. 64, no. 2, 1991, pp. 161-171. https://urn.nsk.hr/urn:nbn:hr:163:396693

Elshani, S., Lj. Butula, I. Butula, D. Vikić Topić, A. Berton and A. Iriarte. "The synthesis of some B6 vitamin halophosphates." Croatica Chemica Acta 64, no. 2 (1991): 161-171. https://urn.nsk.hr/urn:nbn:hr:163:396693

Elshani, S., et al. (1991) 'The synthesis of some B6 vitamin halophosphates', Croatica Chemica Acta, 64(2), pp. 161-171. Available at: https://urn.nsk.hr/urn:nbn:hr:163:396693 (Accessed 16 April 2024)

Elshani S, Butula Lj, Butula I, Vikić Topić D, Berton A, Iriarte A. The synthesis of some B6 vitamin halophosphates. Croatica Chemica Acta [Internet]. 1991 [cited 2024 April 16];64(2):161-171. Available at: https://urn.nsk.hr/urn:nbn:hr:163:396693

S. Elshani, Lj. Butula, I. Butula, D. Vikić Topić, A. Berton and A. Iriarte, "The synthesis of some B6 vitamin halophosphates", Croatica Chemica Acta, vol. 64, no. 2, pp. 161-171, 1991. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:396693. [Accessed: 16 April 2024]

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Metadata
Title (english)The synthesis of some B6 vitamin halophosphates
AuthorS. Elshani
AuthorLj. Butula
MBZ: 6383
AuthorI. Butula
MBZ: 6372
AuthorD. Vikić-Topić
AuthorA. Berton
AuthorA. Iriarte
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
A series of new halo-derivates of pyridoxine-3-O- or 5’-0-phosphates and pyridoxal-3-O- or 5’-0-phosphates have been synthesized. In the reaction of partially protected pyridoxine and pyridoxal (3-5) with phosphorusoxychlo- ride in the presence of triethylamine, the following dichlorophosphates were obtained: 3,4’-0-isopropylidenepyridoxine-5’-0-dichlorophosphate (6), 4,5’-0- isobutilidenepyridoxine-3-O-dichlorophosphate (7), and monoethylacetal-3-O- dicholorophosphate (8). Dichlorophosphates 6-8 reacted with NaF under catalytic action of 18-crown-6-ether, giving the corresponding difluorophos- phates 14-16. The 3,4’-0-isopropyiidene pyridoxine-5’-0-difluorophosphate (14), 4’,5’-isobutilydene-3-0-difluoro-phosphate (15) and monoethylacetal-3-O-di- fluorophosphate (16), in the reaction with aniline, yielded the corresponding monofluorophosphates in the form of aniline salts (17-19). The direct fluor- ination of pyridoxal-5’-phosphate with dinitrofluorobenzene yielded pyridox- al-5’-0-monofluorophosphate (I) which was isolated as cyclohexylamine salt (2).
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 64, no. 2, pp. 161-171
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:396693
Publication1991
Document URLhttps://hrcak.srce.hr/137310
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-29 15:52:50