Farmakološka svojstva odabranih blokatora beta-adrenoreceptora

Professional paper - Professional paper

• Author: Marin Vučić
• Author: Lidija Bach-Rojecky
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

P-blockers are one of the oldest drugs that affect functions of the
cardiovascular system and certainly one of the most commonly
used drugs in general. The spectrum of their application is derived from cardiovascular
diseases, most important of which are arterial hypertension, ischemic
heart disease, chronic heart failure with reduced ejection fraction and cardiac
arrhythmia, up to treatment and/or prevention of migraine headaches and tremors.
Although their basic mechanism of action is antagonism (blockade) of
p-adrenergic receptors, there are significant differences between them in additional
pharmacodynamic effects ( e.g., antagonism of a1 -adrenoreceptors, induction
of NO synthesis, intrinsic sympathomimetic activity), but also in lipophilicity
and pharmacokinetic properties. Therefore, it is not justified to any drug in
this group automatically attribute characteristic of a particular representative.
For this reason, this article attempts to explain all significant differences between
them, having to mind their importance in pharmacotherapy of cardiovascular
diseases.
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• Keywords (croatian): blokatori beta-adrenoreceptora; beta blokatori; kardiovaskularne bolesti
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 75, no. 4, pp. 207-218
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:516533
• Publication: 2019
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-08 08:26:13