Prirodni produkti u terapiji malarije

Professional paper - Professional paper

• Author: Marina Marinović
• Author: Goran Poje
• Author: Zrinka Rajić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Malaria is an infectious disease that mainly affects tropical and
subtropical parts of the world. Despite numerous therapeutics
options, disease eradication is hampered by the development of the resistence.
Many of the known antimalarial drugs are secondary metabolites, i.e. natural
products. Quinine and artemisinine were directly isolated from plants, whereas
others are semisynthetic. Arthemeter and artesunate were obtained by modifying
the artemisinine structure, while atovaquone was developed from a natura!
product lapachole. Antibiotics used in the treatment of malaria (macrolides
and doxycycline) are eighter natural products isolated from bacterial species or
their semisynthetic derivatives. Some other plant families produce secondary
metabolites with antimalarial activity also, which might serve as lead compounds
for the development of novel antimalarial drugs.

• Keywords (croatian): malarija; antimalarici; prirodni produkti
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 75, no. 5, pp. 371-386
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:982388
• Publication: 2019
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-15 13:28:43