Uloga folatne kiseline u sprječavanju defekta neuralne cijevi

Professional paper - Review paper

• Author: Tanja Manzin
• Author: Ana-Marija Domijan
• Author: Srećko Marušić
• Author: Petra Turčić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical botany)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

Neural tube defects (NTDs) are the second most common type of birth
defect. In period of 201 1 til 20 1 5 in Croatia the incidence of NTDs were 4.75
on 10 000 births. Importantly, due to better prenatal diagnosis the incidence of
NTDs is decreasing. The aetiology of NTDs is not known and NTDs are considered
multifactorial disorders. Evidence so far suggests that in development of
NTDs genetics and environmental factors are involved and some studies indicate
importance of folate and/or folic acid deficiency.
Folates are naturally occurring while folic acid is synthetic derivate of
vitamin B9. Due to its stability and better absorption folic acid is used for
supplementation and food fortification. Within the organism folates and folic
acid are involved in numerous metabolic pathways such as synthesis of amino
acids, nucleotides and DNA methylation, indicating that folates and folic acid
are required in the processes that involve higher DNA synthesis as in embryonic
cells.
Studies conducted since 1970s indicate that supplementation with folic acid
(alone or in combination with other vitamins) can reduce NTDs occurrence.
Based on these results, in 1998 USA and some other countries introduced food
( cereals) fortification with folic a cid that has led to the decrease of NTDs occurrence
in these countries for 10 to 80 %. Such fortification is not embraced in
Croatia and other European Union countries due to involvement of folic acid in
DNA methylation and possible development of cancers. Molecular mechanisms
underlying development of NTDs are not known yet. Currently, several molecular
mechanisms of NTDs development are investigated su ch as folate receptor on
plasma membrane, nucleotide synthesis and DNA methylation. Knowledge on
the molecular mechanism of NTDs development will point to the development
of more effective intervention for treatment of NTDs.

• Keywords (croatian): defekt neuralne cijevi; NTD; folatna kiselina; folati
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 74, no. 6, pp. 429-448
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:245323
• Publication: 2018
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-18 10:59:15