Utjecaj parametara sušenja raspršivanjem na svojstva alginatnih mikročestica

Scientific paper - Original scientific paper

• Author: Laura Nižić
• Author: Sabina Keser
• Author: Margareta Duvnjak Romić
• Author: Anita Hafner
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Spray-drying is a technological process that is
widely used in the development of pharmaceuticals. By optimizing
the process parameters, it is possible to obtain the powdered product
of controlled particle properties. The procedure is largely applicable
in the development of innovative drug delivery systems of the desired
release profile of the drug.
The aim of this work was to prepare alginate microparticles by
spray drying method and to investigate the influence of the feed rate
and drying air flow rate (through aspirator setting) on the process
yield, particle size and residual moisture content of the product. A
full factorial experimental design with three levels of process parameters
was used (sample flow rate of 2.12, 3.92 and 5.64 g/min, and
aspirator setting of 25, 50 and 75 % of full capacity ). The sodium
alginate solution (O.S %, w!V) was spray-dried at an inlet temperature
of 140.0 °C and a compressed air flow of 700 Nl/h using a bifluid
nozzle device. Particle size was determined by microscopic image
analysis. Moisture content in dried products was determined by
thermogravimetric analysis. The yield of the spray-drying process
ranged from 40.2 to 59.6 %. Significant influence of the investigated
parameters on the process yield was noted: increasing sample flow
rate resulted in reduced process yield, while the increase of drying air
flow rate caused a greater yield of the process. The mean diameter of
alginate microparticles ranged from 2.80±0.04 μm to 3.14±0.17 μm. SEM analysis revealed the adhesion of smaller particles to larger
ones and the agglomeration oj the particles. The moisture content of
the alginate microparticles ranged from 9.75 to 11.51 %. The relationship
between the microparticle moisture content and the studied
parameters was not observed. Relatively high moisture content in the
spray-dried products was explained by sorption of the atmospheric
moisture on alginate microparticles after the spray-drying process.
This study can serve as a starting point in the development of alginate
based drug delivery systems prepared by spray-drying.

• Keywords (croatian): sušenje raspršivanjem; alginatne mikročestice
• Language: croatian
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 74, no. 9, pp. 619-632
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:866890
• Publication: 2018
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-06-18 11:52:23