Bakterijski biofllmovi - stanična komunikacija

Professional paper - Professional paper

• Author: Branka Zorc
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Bacteria may assume two different life forms: floating (planktonic)
and biofilm forms. In biofilms bacteria exist as heterogeneous
populations with various growth rates embedded in extracellular polymeric
substrate, which functions as a 3D scaffold that provides stability and protection
against antimicrobial treatments and immunological system of the host organism.
The composition of the matrix varies with the microorganism type, local
mechanical shear forces, substrate availability and the host environment.
Current biofilm-targeting strategies involve physical-mechanical and chemical
approaches. Quorum sensing (QS) or cell-to-cell communication represents
an attractive target of antibiofilm drug discovery. Inhibition of QS-regulated
gene expression lead to reduction of virulence factor secretion and biofilm
formation. QS inhibition can be accomplished in different ways, by inhibiting
the signal molecules production, by degrading the signal molecules or by blocking
the signal receptors. Various compounds of natural and synthetic origins
have been reported as efficient antibiofilm agents. They do not directly affect
bacterial survival and thus the expectation is that resistance to these molecules
will not readily occur.
Ability of bacteria to form biofilms complicates treatment of various infections,
especially those related to the use of medical devices. This enhances risks
of health threats and causes a lot of industrial problems. To date, no antibiofilm
drug has been registered although several of them are in clinical trials.

• Keywords (croatian): bakterije; infektivne bolesti; bakterijski biofilmovi; stanična komunikacija; inhibitori stanične komunikacije
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 75, no. 5, pp. 387-394
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:694785
• Publication: 2019
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-07-07 09:27:51