Hidrogelovi za vaginalnu primjenu lijekova

Professional paper - Review paper

• Author: Željka Vanić
• Author: Zora Palac
• Author: Nataša Škalko-Basnet
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

The vaginal route of drug administration has been used for achieving local and
systemic drug effects. The rate and extent of drug absorption after intravaginal application
may be altered by vaginal physiology, age, stage in the menstrual cycle, pathological
condition and formulation factors. Among a variety of vaginal dosage forms
available, hydrogels offer several advantages such as hydrophilicity, biocompatibility,
good distribution and retention, appropriate drug release and acceptability by patients.
They have been mostly used for the treatment of vaginal dryness and local delivery of antimicrobial drugs, microbicides, contraceptives and labor inducers. However, hydrogels have also potential for systemic delivery of hormones, vaccines, proteins and peptides. This paper summarizes potentials, current use and research on hydrogels
as vaginal drug delivery systems.

• Keywords (croatian): vaginalni pripravci; hidrogelovi; vaginalna infekcija; kontraceptivi
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 70, no. 12, pp. 813-826
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:383077
• Publication: 2014
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-07-08 13:27:03