Eikozanoidi i njihovo djelovanje na pojedine organske sustave

Professional paper - Review paper

• Author: Petra Turčić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Eicosanoids are arach.idonic acid derivatives that play a significant role in th.e physiology
and pathophysiology of the human body. Ph.ospholipases present in various cell
types are involved in the release of arachidonic acid th.at can be metabolized by
cyclooxygenases that results information of prostaglandins, prostacyclines and thromboxanes
or by lipooxygenase with the formation of leukotrienes and hydroxyeicosatetraenoic
acids (HETEs); or cytochrome P450 with the formation of epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). The metabolism as well as the
physiologic and pathophysiologic action of eicosanoids is described. Various drugs interfere
with the production and degradation of eicosanoids modifying their effects on the
body. Better understanding of eicosanoid bioactivity could help in the research and identification
of novel pharmaceutical forms suitable for the treatment of diseases such as
autoimmune diseases, inflammation, glomerulonephritis, malignancies, Alzheimer's
disease, etc.

• Keywords (croatian): eikozanoidi; prostaglandini; leukotrieni
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 64, no. 11, pp. 593-604
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:741100
• Publication: 2008
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-09-28 09:22:38