Krkavina (Frangula alnus Mili.) - botanički podaci, fitokemijski sastav i biološki učinci

Professional paper - Review paper

• Author: Matija Salopek
• Author: Ivan Sušanj
• Author: Maja Bival Štefan
• Author: Jasna Jablan
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of analytical chemistry)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Laxative property of dried bark of Frangula alnus Mill. (synonym Rhamnus frangula
L.) is known for centuries and it is still in use in treatment of constipation.
Medicines based on F. alnus bark (Frangulae cortex) according to the EU parliament
and European medicines agency products for human use are considered as medicinal
products with »well-established medicinal use«. Nowadays on Croatian's market are
available F. alnus-based preparations in the form of tea, pills or powders. Laxative
property of F. alnus bark is attributed to its main constituents, anthraquinones, anthracene
derivatives which are class of the pharmacologically active natural compounds.
The main anthraquinone present in the bark of F. alnus is emodin and laxative property
of F. alnus bark is directly connected to emodin. However, recent studies have
shown that biological effects of F. alnus bark and its main antraquinone emodin are
much broader than just a laxative effect. lt is shown that they have antimicrobial,
antiviral, antifungal and antioxidant effect. Furthermore, for emodin is shown antitumour
effect. Except to their positive biological effects, it is demonstrated that bark
of F. alnus and emodin are toxic. Therefore, treatment of constipation with medicines
based on bark of F. alnus should only be considered for short term use.

• Keywords (croatian): krkavina; Frangula alnus Mill. Bark; opstipacija; laksativ; kora krkavine; emodin
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 72, no. 10, pp. 651-670
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:044070
• Publication: 2016
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-09-29 09:48:00