Lijekovi u laktaciji

Professional paper - Professional paper

• Author: Monika Barbarić
• Author: Valnea Zubović
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Most drugs used in treatment of breastfeeding mothers are tentatively safe. The
exposure of breastfeeding mothers to drug or other xenobiotics will generally result in
the transfer of these substances in human milk in low concentrations. The knowledge
about medicines and their characteristics (pKa, solubility in water and lipids, the size
of the molecule, oral bioavailability, toxicity, effects on milk production, t1/2) helps
healthcare professionals in appropriate drug prescribing, in providing an useful information
and patient tracking for possible drug effect in infant. The risk of adverse drug
reactions is highest in children below 2-3 months, and in breastfeeding mothers who
are on psychoactive drugs. According to the FDA classification, drugs used in breastfeeding
are classified into five categories of L1 till L5. Drugs in the category L5, like
radioactive isotopes, ACE inhibitors, estrogens, bromocriptine are strictly contraindicated
in breastfeeding.

• Keywords (croatian): dojenje; laktacija; toksičnost lijeka
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 69, no. 9, pp. 525-538
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:256680
• Publication: 2013
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-09-29 10:12:12