Oksidacijski stres u šećernoj bolesti

Professional paper - Professional paper

• Author: Roberta Petlevski
• Author: Vladimira Kutnjak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (english)

Oxidative stress plays a pivotal role in cellular injury from hyperglycemia. High
glucose level can stimulate free radical production. Increasing evidence in both experimental
and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately
in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the
subsequent oxidative degradation of glycated proteins. Abnormally high levels of free
radicals and the simultaneous decline of antioxidant defense mechanisms can lead to
damage of cellular organelles, and enzymes, increased lipid peroxidation, and development
of insulin resistance.

• Keywords (croatian): oksidacijski stres; oksidacijsko oštećenje tkiva; dijabetes; diabetes mellitus; antioksidansi
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 71, no. 6, pp. 303-308
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:262844
• Publication: 2015
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-10-01 14:17:19