Otkriće i razvoj nekih poznatih lijekova

Professional paper - Professional paper

• Author: Zrinka Rajić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Known strategies for the new drug discovery are systematic screening of the biological
activity of sets of compounds, modifications of the existing active molecules and rational
design. Most of the drugs on the market were developed by a mixture of hard work, trial
and error, rational design, and pure luck. Here we give the overview and some interesting
facts about the discovery and development of some famous drugs, such as statins (cholesterol-
lowering drugs), inhibitors of monoaminoaxidase (antidepressants), propranolol
(selective beta-blocker), tolbutamide (antidiabetic), chlorthiazide (diuretic}, sildenafil (antiimpotence
drug) and disulfiram (treatment of chronic alcoholism).

• Keywords (croatian): statini; inhibitori monooaminooksidaze; propranolol; tolbutamid; klorotiazid; sildenafil; disulfiram
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 67, no. 6, pp. 399-406
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:997006
• Publication: 2011
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-10-01 15:27:39