Psihotropna biljna vrsta Salvia divinorum Epl. & Jativa - izvor najpotentnijeg halucinogena u prirodi

Professional paper - Review paper

• Author: Darija Šarić
• Author: Zdenka Kalođera
• Author: Zdravko Lacković
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

This review article summarizes the current knowledge about the metabolism, pharmacological
effect, traditional and modem therapeutic use and safety of S. divinorum.
Salvia divinorum is a plant of the Lamiaceae family which has a psychoactive, hallucinogenic
effect. The main psychoactive ingredient is diterpene salvinorin A which is considered
the most potent natural hallucinogen. Hallucinogenic doses in humans are estimated
as low as 200-500 μg. ln the traditional medicine the plant is consumed
primarily to encourage shamanic visions in the context of healing or divination, but also
as a drug at lower doses (diuretic, antidiaroic, antianemic, analgesic and antirheumatic).
The research has shown that salvinorin A is a potent K-opioid receptor agonist. K-opioid
receptors agonists are of therapeutic importance in treating pain and possibly drug
addiction, eating disorders, depression, and even in the treatment of human immunodeficiency
virus (HIV). However, salvinorin A represents a new class of selective K-opioid
receptor agonist without nitrogen in its structure. Such agonists have profound influence
on human cognition and perception. There are suggestions that salvinorin A could
be useful in treating certain psychiatric disorders (eg Alzheimer's disease, schizophrenia,
bipolar disorder and dementia). lt also becomes a new molecular candidate in the development
of antipsychotic drugs.

• Keywords (croatian): rod Salvia; Salvia divinorum; meksička kadulja; psihoaktivne biljke; prirodni halucinogeni; salvinorin A
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 66, no. 10, pp. 523-541
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:495946
• Publication: 2010
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-10-02 13:06:01