Transport lijekova iz nosne šupljine u mozak

Professional paper - Professional paper

• Author: Mario Jug
• Author: Mira Bećirević-Laćan
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

The presence of the blood-brain barrier poses a huge challenge to effective delivery of
therapeutics to the centra! nervous system. Therefore, many diseases of the centra! nervous systems, such as Alzheimer's or Parkinson's disease, multiple sclerosis and brain tumors cannot be successfully treated. ln recent years, interest has been expressed in using
the nasal route far delivering drugs to the brain, exploiting the olfactory pathway.
Numerous studies in animal models have reported evidence of nose to brain delivery of
many different drugs, including neuropeptides. T he factors affecting the rate and extent
of drug transport to the brain are molecular weight, lipophilicity and ionization of the
drug. Studies in man have mostly compared the pharmacological effects of nasally and
parenterally applied drugs. The results have confirmed the likely existence of a direct
nose to brain pathway in humans, but demonstration of the clinical feasibility of nose to
brain drug delivery is still doubtful. There is an increasing need far a nasa! drug delivery
system that would improve the efficiency of the direct nose to brain pathway. Novel
approaches capable to combine active targeting of a formulation to the olfactory region
with mucoadhesive characteristics and controlled drug release will probably enhance the
therapeutic use of this pathway.

• Keywords (croatian): transport lijeka; nazalna primjena lijeka; središnji živčani sustav; nosna šupljina
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 63, no. 11, pp. 649-658
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:914327
• Publication: 2007
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-01-07 12:23:16