Bioaktivne sastavnice grimizne rudbekije (Echinacea purpurea (L.) Moench, Asteraceae)

Professional paper - Professional paper

• Author: Ivan Kosalec
• Author: Marina Bakmaz
• Author: Dragomir Brkić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Preparations made with extract of purple coneflower (Echinacea purpurea (L.) Moench.),
as well as those made with other Echinacea species: E. pallida (Nutt.) Nutt. i E.
angustifolia DC. (Asteraceae) are one of the best sold herbal products in Europe and
North America known as herbal immunodulators (immunostimulants). They are
used as a preventive herbal remedy or a help for bacterial and viral infections of the
upper and lower respiratory tract (colds, flu, tonsillitis etc), and bacterial and fungal
infections of the lower urinary tract etc.
Echinacea species are perennial plants that grow wild in centra} and central-east
North America and in the genus Echinacea there are nine species. The most researched
of them are three species: E. purpurea, E. pallida and E. angustifolia. Bioactive
components with immunomodulation activity are lipophylic and polar components in
extract. The most studied out are derivates of caffeic acid, alkylamides and polysaccharides.
With all pharmaceutical preparations made with herbal material there is a problem
of standardisation that is determination of the assay of biological active component(s)
in the biological material or preparation. For preparations made of purple coneflower
for the moment there aren't data about synergistic act on particular components with
immunomodulator activity as well as their bioavailability; adsorption, distribution,
metabolism and elimination.
A long-time use of preparations made of these herbal species show relatively non-toxicity,
but in individual cases there is a possibility of allergic reactions of the immediate
type.
In positive monographs on German »Commision E« there are fresh above-ground parts
(herb) of purple coneflower (Echinaceae purpureae herba) and fresh or dried root of
species E. pallida (Echinaceae pallidae radix).

• Keywords (croatian): grimizna rudbekija; Echinacea purpurea (L.) Moench
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 59, no. 11, pp. 507-519
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:283138
• Publication: 2003
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-16 13:15:00