Prostasomi - organele sjemene tekućine

Professional paper - Professional paper

• Author: Ana Plazonić
• Author: Tihana Žanić-Grubešić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract (english)

Prostasomes are membrane surrounded organelles secreted by epithelial cells of the
prostate gland and are present in normal human semen. Bilaminal or multilaininar
lipoprotein membrane contains a high amounts of cholesterol, sphingomyelin and enzyms.
Prostasomes interact with sperm cells. This fusion is dependent on pH and requires
one or more proteins on sperm and prostasome surfaces. The prostasomes are
ascribed to have many biological functions. They protect spermatozoa in acidic environment,
stabilize sperm plasma membrane and delay acrosome reaction, enhance
sperm motility, inhibit the lymphoproliferation and the phagocytosis of macrophages,
regulate the complement activation, possess an antioxydant capacity and inhibit uiral
activity. Because of their role in regulating sperm motility and viability they could be
used in improving results in assisted reproductive technologies using freeze-thawed
spermatozoa.

• Keywords (croatian): prostasomi; prostata; sjemena tekućina
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 71, no. 11, pp. 599-613
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:857809
• Publication: 2015
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-17 12:45:53