Terapijski sustavi za vaginalnu primjenu

Professional paper - Review paper

• Author: Željka Vanić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (croatian)

The vaginal route of drug administration offers certain unique features that can be
exploited in order to achieve desirable therapeutic effects. Considerable progress has
been made in this research area over the past few years and, at present, the anatomy and
physiology, microflora and secretions of the vagina are well understood. By contrast, the
scientific knowledge regarding the possibilities of drug delivery via the vagina is limited.
To date, there are only a limited number of vaginal dosage forms available, although various
possibilities are explored. Pharmaceutical dosage forms far vagina! delivery are
usually applied far the local treatment of specific gynaecological diseases, such as candidiasis,
vaginosis and sexually transmitted diseases. The currently available vaginal delivery
systems have some limitations, such as leakage, messiness and low residence time, which
contribute to poor subject or patient compliance. Therefore, attempts are being made to develop novel vagina! drug delivery systems (e.g. bioadhesive systems, liposomes) that
can meet the clinical and user's requirements. This review is focused on the various aspects,
scope and potential of vaginal drug delivery.

• Keywords (croatian): vaginalna primjena lijeka; bioadhezivni polimeri; bioadhezivni sustavi; mikrosfere; liposomi
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 61, no. 7-8, pp. 441-453
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:967353
• Publication: 2005
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-18 10:32:57