Lipofilnost lijekova. I. dio: Važnost lipofilnosti u istraživanju novih lijekova

Professional paper - Professional paper

• Author: Marica Medić-Šarić
• Author: Danijela Franić
• Author: Željko Debeljak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Lipophilicity is a prime physicochemical descriptor of xenobiotics with
relevance to their biological properties. The hydrophobic interaction of drugs
with a receptor and the toxicological properties are examples of a steadily
increasing number of topics in which lipophilicity plays an important role.
A number of empirical and theoretical approach have been developed during
the last twenty years for calculation of log P values. The most common experimental
method for determining the equilibria of drugs partitioning between
water and n-octanol is shake-flask method.
In this context calculative approaches are superior to experimental procedures.

• Keywords (croatian): lipofilnost lijekova; biološke membrane; metoda izmućkavanja
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 54, no. 2, pp. 37-51
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:109839
• Publication: 1998
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-03-05 10:42:30