Lipofilnost lijekova. III. dio: Fragmentarni sustav Hanscha i Leoa

Professional paper - Professional paper

• Author: Marica Medić-Šarić
• Author: Danijela Franić
• Author: Željko Debeljak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Lipophilicity is a property of molecular structure which is essential in
predicting the transport and activity of drugs, pesticides and various xenobiotics.
The most important parameter which describes lipophilicity in a numerical
way is partition coefficient P. It describes the manner in which a
bioactive solute partitions between polar and nonpolar phases. For that reason,
beside experimental methods for it's determination, there are developed
numerical approaches for it's calculation. The most common methods are: by
substituting groups for hydrogen (II system) and by summing the appropriate
structural elements (fragment systems). In log P calculations today more
often are in use computer programs based on this methods.
Log P is a widely used parameter in QSAR for quantitative description
of lipophilic character of biologically active compounds. Molecular modeling
in pharmacy and chemistry is used to rationalize drug design process in order
to predict properties and activity, and to reduce the number of compounds
to be synthesized.

• Keywords (croatian): lipofilnost lijekova; QSPR; QSAR
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 54, no. 4, pp. 113-131
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:907594
• Publication: 1998
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-03-05 11:01:28