Imunomodulacijski učinak vrsta roda Echinacea

master's thesis

• Title (english): Immunomodulatory effect of Echinacea species
• Author: Nikolina Škrlec
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky
• Committee member: Marijana Zovko Končić
• Committee member: Sandra Šupraha Goreta
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2015-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Echinacea je zbog svog izražnog imunomodulacijskog učinka jedna od najistraživanijih biljaka današnjice. Unatoč brojnim istraživanjima kemizma, mehanizma djelovanja pojedinih sastavnica, malo je relevantnih na dokazima-utemeljenih podataka o učinkovitosti i sigurnosti iz kliničkih studija. Cilj ovog rada bio je istražiti utemeljenost tvrdnji o imunomodulacijskom djelovanju te istražiti mehanizam istog, prikazati metabolizam, nuspojave i interakcije koje mogu nastati prilikom korištenja preparata koji sadrže Echinaceu, prikazati važnost kontrole kvalitete biljnih droga koje se koriste u kliničkoj primjeni. Mehanizam imunomodulacijskog djelovanja temelji se na povećanju fagocitoze, mobilnosti T limfocita i povećane respiratorne aktivnosti. Protuupalno djelovanje bazirano je na povećanju lučenja protuupalnih, a smanjenja lučenja proupalnih citokina. Metabolizam glavnih aktivnih sastavnica odvija se putem citokroma P450, a zbog inhibicijskog djelovanja na CYP3A4 moguće su interakcije s lijekovima koje taj enzim metabolizira.Terapijski potencijal ove zanimljive biljne vrste temelji se na rezultatima pretkliničkih, ali i sve većeg broja kliničkih studija koje govore u prilog imunomodulacijskog djelovanja. Kako bi se maksimalno iskoristio terapijski potencijal Echinaceae vrsta, a minimalizirao rizik nuspojava i interakcija s drugim lijekovima, potrebno je kontrolirati pripravke koji dolaze na tržište s obzirom na sastav, količinu i kvalitetu sastavnica koje sadrže.

Abstract (english)

Because of it's expressed immunommodulatory effect Echinacea is one of the most investigated medicinal plants. Despite numerous studies of it's chemistry, mechanism of action of main constituents, there is little evidence from clinical studies related to it's efficiency and safety. The main goal of this diploma thesis was to investigate the mechanism of immunomodulatory effect of Echinaceae species. Additionally, aims were to: explain metabolism, describe side effects and interactions which can emerge during usage of preparations which contain Echinacea and to show importance of quality control of herbal medicine used in clinical practice. The mechanism of immunomodulatory effect is based on increased phagocytosis, increased mobility of the T-lymphocytes and increased respiratory activity. Anti-inflammatory effect is based on up-regulation of anti-inflammatory cytokines and down-regulation of pro-inflammatory cytokines. Metabolism of main active components involves reactions catalyzed by cytocrome P450. Because of it's inhibitory effect on CYP3A4, interactions with drugs which are substrates of this enzyme are possible. Therapeutic potential of this interesting plant is based on results from numerous preclinical and growing number of clinial trials which are going in favor oEchinacae immunomodulatory effect. To maximize therapeutic potential of Echinacea and to minimize side effects and interactions we need better quality control of available preparations considering quantity, quality and type of constituents.

• Keywords: ehinacea; echinacea; imunološki sustav; alkilamidi; nuspojave; makrofagi; citokini; dendritične stanice; T-limfociti; protuupalno djelovanje; imunomodulacijsko djelovanje
• Keywords (english): echinacea; immune system; alkyamide; side effects; macrophage; cytokine; dendritic cells; T-lymphocite; anti-inflammatory activity; immunomodulatory activity
• Language: croatian
• URN:NBN: urn:nbn:hr:163:390969
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-02-25 11:30:23