Parenteralni pripravci produljenog oslobađanja temeljeni na inovativnoj tehnologiji polimernih mikročestica

master's thesis

• Title (english): The parenteral preparations with extended release based on the inovative technology of polymer microparticles
• Author: Petar Skelin
• Mentor: Jasmina Lovrić (mentor)
• Committee member: Jasmina Lovrić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-11-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Glavni cilj ovog diplomskog rada bio je prikazati inovativnu tehnologiju polimernih mikročestica
kao tehnologiju koja će zasigurno i mati velik i značaj u budućnosti. Prilikom izrade rada
raspravljalo se o prednostima i nedostatcima tehnologije te o uvjetima proizvodnje koji su jako
specifični budući da se radi o parenteralnim pripravci ma. U radu je navedeno i detaljno opisana
nekoliko pripravaka koji već duže vrijeme postoje na tržištu. Također opisane su i tehnike
proizvodnje i uvjeti koji su strogo specifični . Istraživanje i razvoj ovakvih pripravka je vrlo složen
i neizvjestan proces koji ne jamči uvijek povrat uloženih sredstava. Opisan je cijeli put od priprave
mikročestica pa sve do problema s kojima se susrećemo prilikom same primjene. Na kraju rada su
navedeni parametri o kojima strogo treba voditi računa prilikom proizvodnog procesa.

Abstract (english)

The main aim of this thesis was to present the innovative technology of polymer microparticles as
a technology that will surely be of great importance in the future. In this work it was discussed
about the advantages and disadvantages of technology and the production conditions that are very
specific because these are parenteral formulations. Also some of most recognized and well known
products that have been long available on market are described in detail. In addition, main
manufacturing techniques are described and conditions that are very specific. Research and
development of such preparation is very complex and uncertain process that does not always
guarantee return on investment. The whole process from preparing microparticles to the problems
encountered during the application of drug product are described. At the end, the points to consider
when establishing drug product specifications for parenteral microparticles are named and defined.

• Keywords: biorazgradljive mikročestice; kontrolirano oslobađanje; produljena oslobađanje; parenteralna primjena; PLGA kopolimer
• Keywords (english): biodegradable microparticles; controlled release; sustained release; parenteral administration; PLGA copolymer
• Language: croatian
• URN:NBN: urn:nbn:hr:163:295273
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-04-21 13:28:38