Mikroemulzije kao sustavi za dermalnu i transdermalnu primjenu

master's thesis

• Title (english): Microemulsions as dermal and transdermal delivery systems
• Author: Tomislava Kelava
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić
• Committee member: Jasmina Lovrić
• Committee member: Lovorka Vujić
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2015-08-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Mikroemulzije za dermalnu i transdermalnu primjenu opseţno se ispituju u posljednja dva desetljeća. Suvremena ispitivanja pokazuju da mikroemulzije mogu značajno povećati dermalnu apsorpciju hidrofilnih i lipofilnih lijekova u usporedbi s uobičajenim oblicima, kao primjerice micelarne otopine, liposomske disperzije, emulzije, kreme i masti. Stoga su u mikroemulzije uklopljeni lijekovi različitih terapijskih skupina i provedena su brojna ispitivanja in vivo i in vitro u svrhu liječenja različitih bolesti. Kliničkim ispitivanjima mikroemulzijskih sustava dokazane su brojne prednosti kao što su: poboljšanje dermalne bioraspoloživosti, povećanje penetracije i permeacije, povećanje protuupalne djelotvornosti, smanjenje učestalosti nuspojava, povećanje permeabilnost i stabilnosti lijeka. Kozmetička industrija je stalno u potrazi za novim proizvodima koji kombiniraju dokazanu biološku aktivnost i učinkovit sustav primjene. Mikroemulzije obećavaju kao učinkoviti sustavi primjene kozmeceutika. Koristi ih se za poboljšanje svojstava već postojećih aktivnih sastojaka i postizanje veće komercijalne privlačnosti proizvoda. Prednosti mikroemulzija s ukopljenim kozmeceutikom su: poboljšana dermalna bioraspoloživost i stabilnost kozmeceutika, kontrolirano oslobađanje kozmeceutika sa smanjenom mogućnosti iritacije koţe, olakšano nanošenje i uklanjanje kozmetičkog proizvoda.

Abstract (english)

Microemulsions for dermal and transdermal delivery have been studied extensively in the last two decades. They have been found to enhance significantly the dermal absorption of hydrophilic and lipophilic drugs compared with conventional formulations such as micellar solutions, liposomal dispersions, emulsions, creams and pure oils. Therefore, drugs from different types of groups have been incorporated into microemulsions and a number of in vivo and in vitro experiments have been conducted in order to treat various diseases. Clinical studies have shown the microemulsion system to offer numerous advantages: improved dermal bioavailability, greater penetration and permeation, enhanced anti-inflamatory activity, reduced side effects, increased drug permeability and stability. The cosmetic industry is constantly seeking new products that will combine both proven biological activity and an efficient delivery system. Microemulsions appear to be promising as efficient delivery systems for the cosmetic agents. They can be used to improve both the performance of presently used cosmetic active ingredients and the commercial appeal of the product. Microemulsions with incorporated cosmetic agents allow for increased bioavailability, controlled release of the agents with reduced skin irritation, ease of application and removal of the product.

• Keywords: mikroemulzije; dermalna primjena; transdermalna primjena; lijekovi; permeabilnost; stabilnost; oslobađanje; bioraspoloživost; kozmeceutici
• Keywords (english): microemulsions; dermal delivery; transdermal delivery; drugs; permeability; stability; release; bioavibility; cosmeceuticals
• Language: croatian
• URN:NBN: urn:nbn:hr:163:111351
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-02-29 13:22:55