Polučvrsti oblici za vaginalnu primjenu lijekova

master's thesis

• Title (english): Semi-solid dosage forms for vaginal drug delivery
• Author: Lucija Prižmić
• Mentor: Željka Vanić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Mario Jug (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2019-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Polučvrsti oblici najčešće su korišteni oblici lijekova za vaginalnu primjenu. Većina ih je namijenjena postizanju lokalnog učinka (liječenje vaginalnih infekcija i spolno prenosivih bolesti, tretiranje vaginalne atrofije, induciranje poroda, kontracepcija), no dosta se istražuju i za sistemske učinke. Konvencionalni polučvrsti vaginalni pripravci imaju i nedostatke poput zbog kratkog vremena zadržavanja na mjestu primjene zbog čega nerijetko izostane željeni terapijski učinak. Stoga se velika pažnja posvećuje razvoju vaginalnih formulacija s poboljšanim svojstvima korištenjem mukoadhezivnih i termoosjetljivih polimera, inovativnim tehnologijama aerosola te nanotehnologije. Ovaj diplomski rad daje pregled trenutno dostupnih te inovativnih polučvrstih oblika za vaginalnu primjenu lijekova.

Abstract (english)

Semisolid dosage forms are the most commonly used formulations for vaginal drug administration. Although most of them are intended for a topical drug delivery (treatment of vaginal infections, sexually transmitted diseases, vaginal atrophy, labor induction and contraception), they have potential for achieving systemic drug effects, too. However, the conventional semisolid formulations have some limitations such as low residence time on vaginal surface, which can lead to an unsuccessful therapy. Therefore, there is a great interest in developing an advanced vaginal formulations based on the use of mucoadhesive and/or thermosensitive polymers, innovative aerosol technology and nanotechnology. This diploma thesis provides an overview of the currently available and innovative semisolid dosage forms for vaginal drug delivery.

• Keywords: vaginalni ljekoviti oblici; polučvrsti farmaceutski oblici; mukoadhezivni polimeri; termoosjetljivi gelovi; nanotehnologija
• Keywords (english): vaginal drug delivery; semi-solid dosage forms; mucoadhesive polymers; thermosensitive polymers; nanotechnology
• Language: croatian
• URN:NBN: urn:nbn:hr:163:450644
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-10 14:17:20