Farmaceutsko-kemijsko oblikovanje biološki aktivnih supstancija

Professional paper - Professional paper

• Author: Dušica Maysinger
• Author: Nikola Blažević
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

In attempt to obtain the drugs with optimal biological parameters, many different
derivatives of the known drugs are synthetized recently. This principle
known as prodrug concept is a very interesting pathway to better medicines.
In this paper we have discussed the definition of prodrug and some chemical
modifications which can improve physico-chemical properties of the biological
active compounds. Among others the methods to improve liposolubility, stability
and resorption were discussed. How to prolong the action of drugs, to reduce the
toxicity and irritation at the site of application was pointed out. Short survey
dealing with the most popular methods to study structure - activity relationship
and drug design were presented.

• Keywords (croatian): oblikovanje lijekova; prolijek; prolijek supstancije
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 36, no. 4, pp. 113-124
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:651845
• Publication: 1980
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-06-15 15:38:54