Liposomi kao nosači djelatnih tvari biljnog porijekla

master's thesis

• Title (english): Liposomes as carriers for bioactive compounds of herbal origin
• Author: Mirna Palac
• Mentor: Željka Vanić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Renata Jurišić Grubešić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2019-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Biološki aktivni spojevi poput alkaloida, terpena, polifenola i saponina mogu biti izolirani iz biljaka te se potom koristiti kao lijekovi ili kao ishodišne sirovine za razvoj novih (polu)sintetskih lijekova. Međutim, djelatne tvari biljnog porijekla uglavnom su kompleksne organske molekule, velike molekulske mase, kemijski nestabilne i slabe topljivosti što ograničava njihovu kliničku primjenu zbog loše apsorpcije te posljedično niske bioraspoloživosti. Uklapanjem u biorazgradive i biokompatibilne nanosustave moguće je poboljšati farmakokinetička i farmakodinamska svojstva biljnih lijekova i time značajno unaprijediti terapiju. Među brojnim istraživanim nanosustavima primjena liposoma je od iznimnog značaja zbog mogućnosti postizanja ciljane terapije na nivou oboljelih organa, tkiva ili unutarstaničnom nivou, potenciranja biološkog učinka, povećanju stabilnosti uklopljenog biljnog materijala, povećanja bioraspoloživosti, poboljšanog sigurnosnog profila formulacije, smanjenja neželjenih nuspojava i toksičnosti na zdrave stanice. Provedena najznačajnija ex vivo, in vivo i klinička istraživanja obuhvaćena ovim radom sistematizirano su prikazana prema kemizmu uklopljene djelatne tvari.

Abstract (english)

Biologically active phytochemicals such as alkaloids, terpenes, polyphenols and saponins can be isolated from plants and formulated as drugs or used as crude materials for development of (semi)synthetic drugs. Generally, phytochemicals are complex organic molecules, characterized by a large molecular weight, chemical instability and low water solubility, causing poor absorption, low bioaivailability and therefore limited clinical use. Incorporation of phytochemicals into biodegradable and biocompatible nanosystems can improve their pharmacokinetic and pharmacodynamic properties and thus significantly enhance the therapeutic outcome. Among the numerous investigated nanocarriers, liposomes have been demonstrated to be particularly suitable due to the proven ability to: achieve accumulation of the phytochemicals in the diseased tissues or intracellularly, potentiate biological effects and bioaivailability, enhance stability of the incorporated plant material, promote safety profile of the formulation and decrease undesirable side effects or potential citotoxicity. This work presents an overview of the selected ex vivo, in vivo and clinical investigations, systematized according to the chemical features of the incorporated phytoconstituent.

• Keywords: liposomi; biljne djelatne tvari; topljivost; bioraspoloživost; biološki učinci
• Keywords (english): liposomes; phytochemicals; solubility; bioavailability; biological activity
• Language: croatian
• URN:NBN: urn:nbn:hr:163:760033
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-09-08 08:32:10