Antracenski derivati u pripravcima sene i krkavine na hrvatskom tržištu

professional thesis

• Author: Tea Horvacki Zivalov
• Mentor: Biljana Blažeković (mentor)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Antracenski derivati skupina su farmakološki aktivnih prirodnih spojeva izraženog
laksativnog djelovanja i glavne su djelatne sastavnice biljnih droga i pripravaka sene i
krkavine. U okviru rada dat je pregled najnovijih saznanja o primjeni droga Sennae
folium, Sennae fructus i Frangulae cortex kao laksativa, njihovom fitokemijskom
sastavu, mehanizmima djelovanja, te kliničkim dokazima njihove učinkovitosti. S
ciljem usporednog vrjednovanja kakvoće fitopreparata sene i krkavine dostupnih u
Republici Hrvatskoj, u radu su provedena fitokemijska ispitivanja propisana u
relevantnim monografijama Europske farmakopeje (Ph. Eur. 7). Provedena je
identifikacija biljnih droga i pripravaka sene i krkavine, temeljena na dokazivanju
prisutnosti djelatnih senozida i glukofrangulina. Poseban naglasak u radu stavljen je
na određivanje sadržaja antracenskih derivata, kao najznačajnijeg pokazatelja
njihove kakvoće odnosno terapijske djelotvornosti. Utvrđeno je da svi uzorci koji su u
prometu kao biljni lijekovi zadovoljavaju zahtjeve propisane Farmakopejom, dok oni
iz ostalih regulatornih skupina imaju dosta širok raspon sadržaja djelatnih tvari.
Farmakopejske metode primijenjene su i za kvantifikaciju antracenskih derivata u
višekomponentnim fitopreparatima sene i krkavine. Razlike u sadržaju određivanih
markera upućuju na potrebu standardizacije biljnog materijala i ekstrakata s ciljem
osiguravanja kakvoće gotovog pripravka, a time i njegove učinkovite i sigurne
primjene. Uočena je i potreba za razvojem i implementacijom novih, suvremenijih i
bržih metoda za identifikaciju i kvantifikaciju pojedinih antracenskih sastavnica,
posebice u sve zastupljenijim kombiniranim pripravcima. Rezultati rada ukazuju i na
potrebu usklađivanja i unaprjeđivanja legislative u području biljnih pripravaka, sa
svrhom zaštite zdravlja pacijenata.

Abstract (english)

Anthracene derivatives are class of the pharmacologically active natural compounds
with laxative activity, and known to be the main constituents of senna and frangula.
Within this study, knowledge on the medicinal properties of the Cassia and Frangula
plants is enlarged by recent scientific reports on their phytochemical composition, in
vitro and in vivo studies on the mechanisms of their activity and toxicity as well as the
clinical proof of their efficiency. Comparative phytochemical analyses of senna- and
frangula- containing medicinal products were performed according to appropriate
European Pharmacopoeia monographs, with a goal to evaluate and compare the
quality of all anthracen laxatives available on the Croatian market. Identification of
studied herbal drugs and their preparations was based on detection of active
sennosides and glucofrangulins. Special emphasis was given to determination of
total anthracene derivatives contents, as the most important indicator of the herbal
medicine quality and therapeutic effectiveness. All products registered as herbal
drugs complied with prescribed requirements, while phytotherapeutics belonging to
other regulatory categories showed a wide variation in anthracene derivatives
content. Pharmacopoeial methods were also applied for quality control of multicomponent
herbal preparations containing senna- or frangula-herbal drugs.
Considerable differences in contents of marker compounds suggested that
standardization of raw plant material and extracts may be necessary for quality
assurance of herbal medicines and also for their effective and safety use. There is a
need for development and implementation of new, modern and faster methods for
identification and quantification of anthracene constituents, especially for analyses of
polyherbal preparations. The results indicated the need for harmonisation and
improvement of legislation in the field of herbal preparations, in order to protect the
health of patients.

• Keywords: antracenski derivati; fitoterapija; fitopreparati; opstipacija; laksativi; sena; krkavina
• Keywords (english): anthracene derivatives; phytotherapy; phytotherapeutics; constipation; laxatives; senna; frangula
• Language: croatian
• URN:NBN: urn:nbn:hr:163:374912
• Study programme: Title: Drug development; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra razvoja lijekova (sveučilišni magistar/sveučilišna magistra razvoja lijekova)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-03-03 11:09:05