Komplementarna i alternativna medicina: probiotici kao modalitet u prevenciji i tretmanu virusnih infekcija gornjeg dišnog sustava

master's thesis

• Title (english): Complementary and alternative medicine: probiotics as a modality in prevention and treatment of viral infections of the upper respiratory tract
• Author: Hrvoje Banožić
• Mentor: Renata Jurišić Grubešić (mentor)
• Committee member: Renata Jurišić Grubešić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Živka Juričić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2021-04-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Diplomski rad uključuje recentna saznanja o djelovanju probiotika na akutne virusne infekcije gornjeg dišnog sustava, kao što su prehlada, sinusitis, faringitis, laringotraheobronhitis, epiglotitis, rinosinusitis, akutna upala srednjeg uha itd. Prema definiciji Svjetske zdravstvene organizacije, probiotici su živi mikroorganizmi koji, kada se koriste u odgovarajućoj dozi, pružaju domaćinu zdravstvenu korist. Upotreba probiotika predlaže se već dugo za sve više indikacija. No, uslijed sve većeg interesa, dostupnosti i različitosti konačnih proizvoda, postoji zabrinutost da se prihvaćaju bez kritičke ocjene, kvalitetne regulatorne kontrole, te bez dovoljno dokumentiranih znanstvenih dokaza za zdravstvenu korist kod pojedinih patoloških stanja i za pojedine probiotičke formulacije. Probiotici imaju svoju indikaciju i pri njihovoj upotrebi važno je koristiti soj i dozu CFU sukladno kliničkim studijama i preporukama nadležnih tijela. Lactobacillus rhamnosus GG (LGG) jedan je od najispitivanijih probiotičkih sojeva na svijetu, čija je učinkovitost i sigurnost klinički potvrđena te se prema europskim i svjetskim smjernicama kao stupanj preporuke A preporučuje u prevenciji proljeva izazvanog antibioticima, prevenciji kolika kod dojenčadi, terapiji akutnog proljeva i prevenciji respiratornih infekcija kod djece. Klinička ispitivanja pokazala su značajno smanjenje trajanja i učestalost pojave virusnih infekcija gornjeg dišnog sustava pri primjeni LGG kulture, a sve više ispitivanja istražuje i potencijalnu korist kod ostalih indikacija vezanih za dišni sustav (astma, alergijski rinitis itd.). Učinkovitost LGG-a u prevenciji respiratornih infekcija ima pozadinu u složenom imunomodulacijskom učinku te posljedično usklađenoj imunosnoj komunikaciji crijevne mikroflore i sluznice dišnog sustava.

Abstract (english)

The thesis includes the latest findings on the effect of probiotics on acute viral infections of the upper respiratory tract, such as cold, sinusitis, pharyngitis, laryngotracheobronchitis, epiglottitis, rhinosinusitis, otitis media, etc. According to the definition of the World Health Organization, probiotics are living microorganisms that, when used in the appropriate dose, provide the host with health benefits. The use of probiotics has long been proposed for more and more indications, but due to the growing interest, availability and diversity of final products, there are concerns that they are accepted without critical evaluation, quality regulatory control, and sufficiently documented scientific evidence for health benefits in certain pathological conditions and probiotic formulations. Probiotics have their own indication and when using them it is important to use a strain and a CFU dose in accordance with clinical studies and the recommendations of representative authorities. Lactobacillus rhamnosus GG (LGG) is one of the most tested probiotic strains in the world whose efficacy and safety have been clinically confirmed and is recommended according to European and world guidelines as a grade of recommendation A in the prevention of antibiotic-induced diarrhea, prevention of colic in infants, treatment of acute diarrhea, and prevention of respiratory infections in children. Clinical trials have shown a significant reduction in the duration and incidence of upper respiratory tract viral infections with use of LGG culture, and more and more trials are investigating the potential benefit of other respiratory indications (asthma, allergic rhinitis, etc.). The effectiveness of LGG in the prevention of respiratory infections has a background in a complex immunomodulatory effect and consequently coordinated immune communication of the intestinal microflora and the mucous membranes of the respiratory system.

• Keywords: probiotici; URTI; COVID-19; Lactobacillus
• Keywords (english): probiotics; URTI; COVID-19; Lactobacillus
• Language: croatian
• URN:NBN: urn:nbn:hr:163:775014
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-02 08:54:06