Primjena psihodelika u terapiji bolesti središnjeg živčanog sustava

master's thesis

• Title (english): Use of psychedelics in the treatment of the central nervous system diseases
• Author: Hana Lujanac
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Ivan Pepić (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2021-05-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom radu prikazana je povijesna primjena tvari iz skupine psihodelika, njihova glavna farmakološka obiljeţja temeljena na velikom broju pretkliničkih i kliničkih istraživanja te rezultati recentnih kliničkih studija. Klasični serotoninski psihodelici, vjerojatno djelovanjem preko 5-HT2A receptora, su pokazali pozitivan učinak u liječenju psihičkih oboljenja kao što su depresija, anksioznost, opsesivno-kompulzivni poremećaj, autizam, zatim ovisnosti poput alkoholizma i ovisnosti o nikotinu. U radu su prikazani neki temeljni, pretpostavljeni mehanizmi kojima psihodelici ostvaruju pozitivne terapijske učinke, kao i njihove prednosti i nedostaci u odnosu na konvencionalnu terapiju. Međutim, unatoč velikom napretku u istraživanjima, i dalje se nedovoljno zna o točnim mehanizmima terapijskog djelovanja psihodelika. Ostaje daljnjim istraživanjima ispitati točan farmakodinamski profil, kako bi se moglo točno odrediti koji psihodelik najbolje djeluje u kojoj indikaciji, u kojoj dozi ga je potrebno primijeniti te koji su rizici dugotrajne primjene, posebice za određene rizične skupine bolesnika. Ovim otkrićima otvoren je put ka razvoju novih učinkovitijih i sigurnijih terapijskih opcija različitih psihičkih bolesti, kako bi se oboljelima omogućila što bolja terapija te veća kvaliteta života.

Abstract (english)

This paper presents historical use of substances from the class of psychedelics, their main pharmacological characteristics that are based on a large number of preclinical and clinical studies and the results of recent clinical studies. Classical serotonin psychedelics, presumably by acting via 5-HT2A receptors, have shown a positive effect in the treatment of mental illnesses such as depression, anxiety, obsessive-compulsive disorder, autism and addictions like alcoholism and nicotine addiction. The paper presents some basic, assumed mechanisms by which psychedelics achieve positive therapeutic effects, as well as their advantages and disadvantages compared to conventional therapy. However, despite great advances in research, knowledge about the exact mechanisms of therapeutic action of psychedelics is still insufficient. By further research it remains to examine the exact pharmacodynamic profile in order to determine exactly which psychedelic works best in which indication, in what dose it should be used and what are the risks of long-term use, especially for certain risk groups of patients. These discoveries paved the way for the development of new more effective and safer therapeutic options for various mental illnesses in order to provide patients with the best possible therapy and a higher quality of life.

• Keywords: psihodelici; LSD; meskalin; psilocibin; ayahuasca; halucinogen; psihičke bolesti; ispitivanja na životinjama; kliničke studije; terapija; farmakologija; serotoninski receptori
• Keywords (english): psychedelic; LSD; mescalin; psylocibine; ayahuasca; hallucinogen; mental diseases; animal experiments; clinical studies; therapy; pharmacology; serotonin receptors
• Language: croatian
• URN:NBN: urn:nbn:hr:163:563318
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-02 09:21:34