Prognostički značaj predoperativnih računskih hematoloških upalnih parametara kod pacijentica s karcinomom dojke

master's thesis

• Title (english): The prognostic value of preoperative calculated haematological inflammatory markers in patients with breast carcinoma
• Author: Karmela Ana Popović
• Mentor: Donatella Verbanac (mentor)
• Mentor: Ivan Milas (mentor)
• Committee member: Donatella Verbanac (predsjednik povjerenstva)
• Committee member: Olga Gornik Kljaić (član povjerenstva)
• Committee member: Ivan Milas (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology); Zagreb
• Defense date and country: 2021-09-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract

Prema procjeni podataka dobivenih putem GLOBOCAN-a (interaktivne platforme koja iznosi globalne statistike pojavnosti karcinoma s ciljem informiranja javnosti o kontroli i istraživanjima u tom području) i Registra za rak Republike Hrvatske, dojka je najčešće sijelo karcinoma u žena (učestalost oko 24%). Karcinom dojke uvjetovan je mnoštvom genetskih, kao što su mutacije u BRCA genima, ali i okolišnim čimbenicima, poput ionizirajućeg zračenja, prehrane, endogenih i egzogenih čimbenika te spolnih hormona. U istraživanju provedenom na Klinici za tumore KBC Sestre milosrdnice u Zagrebu ispitivala se povezanost neizravnih hematoloških parametara, omjera neutrofila i limfocita – NLR, omjera trombocita i limfocita – PLR, indeksa sustavnog imunosno-upalnog odgovora – SII s ishodima liječenja i preživljenja u pacijentica koje su se liječile od karcinoma dojke u razdoblju od 2015. do 2021. godine. U ovo retrospektivno istraživanje bilo je uključeno 192 žena te su prikupljeni klinički i hematološko-biokemijski podatci . Hi-kvadrat testom utvrđena je statistička značajna ovisnost NLR omjera i SII indeksa u odnosu na dob pacijentica: mlađe pacijentice imale su više vrijednosti NLR omjera (P=0,025) i SII indeksa (P<0,001) u odnosu na starije pacijentice. Pri graničnoj vrijednosti NLR omjera od 2,65 (P=0,001) i 3,30 (P<0,001) primijećena je tendencija pada vrijednosti NLR omjera nakon operacije. Za SII indeks također je utvrđen značajni pad vrijednosti nakon operacije (P<0,001). Ovim istraživanjem zaključilo se kako je SII indeks superiorniji i sveobuhvatniji nad parametrima definiranim NLR i PLR omjerom, a da optimalna granična vrijednost za NLR omjer iznosi 2,65.

Abstract (english)

The breast is the most common carcinoma site in women (frequency about 24%), according to the GLOBOCAN’s (interactive web page which presents global statistical data about the incidence of carcinoma to inform about control options and researches from this field of science) and the Croatian national cancer record’s data. Breast carcinoma is affected by lots of genetic factors, such as mutations in the BRCA genes. Moreover, breast carcinoma is also influenced by environmental factors like radiation, nutrition, endogenous and exogenous factors, and sex hormones. During the period of 2015 to 2021, a retrospective research was done at the Tumor Clinic of the KBC Sestre milosrdnice in Zagreb, to investigate the relationship between indirect haematological factors, neutrophil to lymphocyte ratio – NLR, platelets to lymphocyte ratio – PLR, systemic immune-inflammation index – SII and the treatment outcome as well as overall survival of patients after 5 years. 192 women with breast carcinoma were included in this research. Clinical and haematological-biochemical data were collected from all women. The Hi-quadrat test determined a statistically significant correlation between NLR and SII with the age of the patients: younger women had higher values of NLR (P=0.025) and SII (P<0.001) compared to older women. At a cut-off value of 2.65 (P=0.001) and 3.30 (P<0.001), a decline in the NLR value was noticed after surgery. The same decline in value after surgery was noticed for the SII (P<0.001). Through this research, SII has been shown to be superior and more comprehensive than parameters set by NLR and PLR. Also, this research recommends 2.65 as the optimal cut-off value for NLR in predicting a successful surgery.

• Keywords: karcinom dojke; neutrofili; limfociti; NLR omjer; trombociti; PLR omjer; SII indeks
• Keywords (english): breast carcinoma; neutrophils; lymphocytes; NLR ratio; platelets; PLR ratio; SII index
• Language: croatian
• URN:NBN: urn:nbn:hr:163:687852
• Study programme: Title: Medical biochemistry; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra medicinske biokemije i laboratorijske medicine (magistar/magistra medicinske biokemije i laboratorijske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-04 13:07:28