Antibakterijski učinak tvari prirodnog porijekla u kombinaciji s lijekovima za liječenje bakterijskih infekcija

master's thesis

• Title (english): Antibacterial effect of substances of natural origin in combination with drugs for treatment of bacterial infections
• Author: Nikolina Hrsan
• Mentor: Monika Barbarić (mentor)
• Committee member: Monika Barbarić (predsjednik povjerenstva)
• Committee member: Cvijeta Jakobušić Brala (član povjerenstva)
• Committee member: Daniela Jakšić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry); Zagreb
• Defense date and country: 2021-07-06, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Antibiotska rezistencija u posljednje vrijeme čini velik globalni zdravstveni problem. Tome se pokušava doskočiti na različite načine poput racionalnijeg propisivanja lijekova, kako bi se umanjila pojavnost rezistencije, ali i smanjile nuspojave i toksični učinci. U novije vrijeme predmet istraživanja su i kombinacije različitih lijekova i/ili lijekova s prirodnim bioaktivnim tvarima. U ovom radu obrađeno je niz istraživanja antibakterijskog učinka bioaktivnih tvari biljnog porijekla (ekstrakti i/ili ulja cimeta, origana, paprene metvice, timijana, katalpovki, ljepljivog omana, žutog ana-ciklusa, ečeverije, mageljanove bobice, kurkume, lovora, marelice, bodljikavog lisnatog jasena, bra-zilskih palmi, araka, barbadoškog oraščića i ružmarinske kiseline), životinjskog porijekla (bakterija iz puža Truncatella guerinii i propolis) ili porijeklom iz gljiva samih ili u kombinaciji s antibioticima koji se koriste u terapiji. Rezultati tih istraživanja pokazuju uglavnom pozitivne sinergističke učinke. Može se zaključiti da bi se, obzirom na obećavajuće pozitivne rezultate, daljnjim istraživanjima ove kombinacije mogle primijeniti i u terapiji.

Abstract (english)

Antibiotic resistance has recently become a major global health problem. It is being addressed in various ways, such as rational drug prescription to reduce the incidence of resistance and side or toxic effects. In recent times the subject of research is also the combination of different drugs and/or drugs with natural bioactive substances. This paper summarizes a number of studies of the antibacterial effect of bioactive substances of plant origin (extracts and/or oils of cinnamon, oregano, peppermint, thyme, catalpa, sticky oman, yellow anacyclus, echeverria, magellanic berry, turmeric, laurel, apricot, shiny-leaf prickly-ash, Brazilian palms, arachnids, barbadian nut and rosemary acid), animal origin (bacteria from the snail Truncatella guerinii and propolis) or originating from fungi alone or in combination with antibiotics used in therapy. The results of these studies show mostly positive synergistic effects. It can be concluded that, given the promising positive results, with further research this type of medication could be applied in therapy.

• Keywords: antibiotici; antibiotska rezistencija; otporni sojevi; antimikrobna aktivnost; interakcije lijekova; biljni ekstrakti
• Keywords (english): antibiotics; antibacterial resistance; resistant strains; antimicrobial activity; drug interaction; plant extracts
• Language: croatian
• URN:NBN: urn:nbn:hr:163:755264
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-10 15:42:06