Mogućnosti primjene cimeta u kontroli šećerne bolesti tipa 2

professional thesis

• Title (english): Potential use of cinnamon to control type 2 diabates
• Author: Marina Šantić
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Jelena Filipović-Grčić (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Dubravko Jelić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2021-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je pregled znanstvenih spoznaja o antidijabetičkom učinku cimeta, s naglaskom na rezultatima kliničkih studija.
Materijal i metode
Istraživanje u okviru ovog rada je teorijskog karaktera i uključuju pregled dostupne znanstvene i stručne literature o predloženoj temi. U pretraživanju su korištene bibliografske baze podataka kao što su: Current Contents, ScienceDirect, Scopus, PubMed, Medline, Cochrane Library i Lexicomp.
Rezultati
Istraživanjima u uvjetima in vitro i in vivo ustanovljeno je da cimet povećava osjetljivost na inzulin, stimulira unos glukoze u stanicu, potiče metabolizam glukoze i sintezu glikogena, inhibira glukogenezu, stimulira oslobađanje inzulina te smanjuje intestinalnu apsorpciju glukoze nakon obroka. Najveći doprinos antidijabetičkom djelovanju cimeta pripisuje se cimetnom aldehidu i oligomernim proantocijanidinima. Kliničke studije su pokazale da cimet snižava razinu glukoze u krvi, glikoliziranog hemoglobina A1c (HbA 1c) i krvnog tlaka te da poboljšava lipidni profil u osoba sa šećernom bolešću tipa 2.
Zaključci
Dosadašnja istraživanja ukazala na veliki potencijal cimeta u kontroli šećere bolesti i otkrivanju novih antidijabetika. No, potrebne su buduće kontrolirane kliničke studije koje će omogućiti njegovu primjenu temeljenu na dokazima u svrhu prevencije i liječenja.

Abstract (english)

Objectives
The aim of this work is to review the scientific findings on antidiabetic effect of cinnamon, with an emphasis on the results of clinical studies.
Material and methods
Research in this work is a theoretical one and includes a detailed overview of the available professional and scientific data on the topic. Bibliographic database such as Current Contents, ScienceDirect, Scopus, PubMed, Medline, Cochrane Library and Lexicomp are searched.
Results
In vitro and in vivo studies demonstrated that cinnamon increases insulin sensitivity, stimulates glucose uptake, promotes glucose metabolism and glycogen synthesis, inhibits glucogenesis, stimulates insulin release, and reduces intestinal glucose absorption after a meal. The highest contribution to antidiabetic activity is attributed to cinnamic aldehyde and oligomeric proanthocyanidins. Clinical studies have shown that cinnamon reduces blood glucose levels, glycated hemoglobin A1c (HbA 1c) and blood pressure, and improves the lipid profile in people with type 2 diabetes.
Conclusion
Previous research showed a great potential for control type 2 diabetes and discovery of new antidiabetic drugs. However, further controlled clinical trials are required to enable its evidence-based application in prevention and therapy.

• Keywords: cimet; dijabetes tipa 2; šećerna bolest tipa 2; antidijabetici
• Keywords (english): cinnamon; type 2 diabetes; antidiabetic drugs
• Language: croatian
• URN:NBN: urn:nbn:hr:163:113693
• Study programme: Title: Drug development; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra razvoja lijekova (sveučilišni magistar/sveučilišna magistra razvoja lijekova)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-15 12:47:24