Uloga dugodjelujućih antipsihotika u terapiji shizofrenije

professional thesis

• Author: Katarina Štritof
• Mentor: Miroslav Herceg (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Miroslav Herceg (član povjerenstva)
• Committee member: Vesna Bačić Vrca (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; Zagreb
• Defense date and country: 2022, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj ispitivanja: Cilj ovog rada je pregledno prikazati ulogu dugodjelujućih antipsihotika u terapiji shizofrenije, opisati njihove prednosti i nedostatke u odnosu na oralne oblike antipsihotika, prikazati njihov značaj kod problema neadherencije shizofrenih bolesnika, te se osvrnuti na pitanje politerapije u liječenju shizofrenije. Očekivani doprinos ovog rada je u brizi i pružanju podrške pacijentima sa shizofrenijom i sličnim poremećajima, s kojima se ljekarnici u radu svakodnevno susreću.
... More Materijal i metode: Pretražena je relevantna znanstvena i stručna literatura, psihijatrijski dijagnostički priručnici, suvremene i važeće terapijske smjernice, publikacije stručnih institucija, baza lijekova Agencije za lijekove i medicinske proizvode, te drugi raspoloživi izvori. Ključne riječi za pretraživanje baze podataka uključivale su sljedeće pojmove: antipsychotics, long-acting antipsychotics, nonadherence, polytherapy, schizophrenia.
Rezultati: Iako je napredak u liječenju shizofrenije značajno smanjio teret bolesti, loša adherencija jedna je od glavnih prepreka u postizanju zadanih terapijskih ciljeva, pa je kontinuitet u liječenju shizofrenije ključan. Na adherenciju u shizofreniji utječe više čimbenika (uvid u bolest, kognitivna oštećenja, politerapija, nuspojave lijekova i mnogi drugi). Dugodjelujući antipsihotici za intramuskularnu primjenu razvijeni su s primarnim ciljem djelovanja na lošu adherenciju. Brojna ispitivanja pokazala su određene prednosti dugodjelujućih antipsihotika u usporedbi s oralnim formulacijama: bolju adherenciju, smanjen rizik za recidiv, smanjen rizik ponovne hospitalizacije i posljedično manje troškove liječenja.
Zaključak: Dugodjelujući antipsihotici se zbog različitih razloga propisuju još uvijek u maloj mjeri. S obzirom na dokazane određene prednosti koje posjeduju, postoji potencijal za njihovu veću primjenu. Less

Abstract (english)

Objectives: The aim of this paper is to do a review of the role of long-acting injectable antipsychotics in the treatment of schizophrenia, to describe their advantages and disadvantages over oral forms of antipsychotics, to show their importance in the problem of nonadherence in schizophrenia treatment, and to address polytherapy in schizophrenia. The expected contribution of this work is in the care and support of patients with schizophrenia and similar disorders, which pharmacists... More encounter on a daily basis.
Materials and Methods: Relevant scientific and professional literature, psychiatric diagnostic manuals, contemporary and currently relevant therapeutic guidelines, publications of professional institutions, drug database of the Agency for Medicinal Products and Medical Devices, and other available sources were searched. Database search keywords include the following terms: antipsychotics, long-term antipsychotics, nonadherence, polytherapy, schizophrenia.
Results: Although advances in the treatment of schizophrenia have significantly reduced the burden of disease, poor adherence is one of the main obstacles to achieving the set therapeutic goals, and continuity in the treatment of schizophrenia is crucial. Adherence in schizophrenia is affected by several factors (insight, cognitive impairment, polytherapy, side effects, and many others). Long-acting injectable antipsychotics for intramuscular use have been developed with the primary goal of acting on poor adherence. Numerous studies have shown certain advantages of long-acting antipsychotics compared to oral formulations: better adherence, reduced risk of recidive, reduced risk of rehospitalization, and consequently lower treatment costs.
Conclusion: Long-acting injectable antipsychotics are still prescribed to a small extent for a variety of reasons. Considering their proven advantages, there is potential for larger use. Less

• Keywords: shizofrenija; antipsihotici; politerapija; adherencija
• Keywords (english): schizophrenia; antipsychotics; polytherapy; adherence
• Language: croatian
• URN:NBN: urn:nbn:hr:163:001542
• Study programme: Title: Clinical pharmacy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/sveučilišna magistra kliničke farmacije (sveučilišni/a magistar/sveučilišna magistra kliničke farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-15 14:39:29