Posebnosti lokalne primjene s ciljem postizanja lokalnog učinka lijeka

master's thesis

• Title (english): Special features of the local administration with the aim of achieving local drug effect
• Author: Viktor Sarić
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić
• Committee member: Jasmina Lovrić
• Committee member: Iva Mucalo
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2015-06-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Lokalna primjena lijekova s ciljem postizanja lokalnog učinka uključuje primjenu lijeka na mjesto njegovog učinka; sistemski učinak lijeka je potrebno u što većoj mjeri ograničiti i smatra se nuspojavom takvog lijeka. Diplomskim radom su obuhvaćeni lijekovi za primjenu na kožu (primjerice u obliku krema i masti); lijekovi za primjenu udisanjem u pluća (primjerice u obliku stačenih inhalata i praška inhalata); lijekovi za primjenu u prednji segment oka (primjerice u obliku suspenzija i otopina); lijekovi za primjenu u nos (primjerice u obliku suspenzija i otopina); lijekovi za primjenu u radnicu (primjerice u obliku gelova, krema, tableta i vagitorija). Svaka promjena farmaceutsko-tehnoloških značajki opisanih oblika može značajno utjecati na djelotvornost i sigurnost primjene lijeka. Promjene fizičko-kemijskih značajki farmaceutskog oblika lijeka ili promjene vrste i udjela pomoćnih tvari u lijeku mogu utjecati na obim i brzinu apsorpcije djelatne tvari nakon lokalne primjene.

Abstract (english)

Locally acting products are products which are applied locally and are assumed to exert their effect at the site of application; systemic action, if any, would be considered as an undesired effect. Examples are dermatological products (e.g. in the forms of creams, ointments), inhalatory products like powders or aerosols for inhalation, eye drops (e.g. in the forms of suspensions, solutions), nasal products (e.g. in the forms of suspensions, solutions), vaginally applied products which act locally (e.g. in the forms of gels, creams, tablets and suppositories). ln these products a change in formulation or in dosage form may influence the efficacy and /or safety- of the product. This may occur for instance by changing the physicochemical properties of the product or by changing the non-active ingredients and thereby the extent of penetration of the active compound.

• Keywords: lokalna primjena lijekova; nuspojave lijekova
• Keywords (english): local drug delivery; side effects of drugs
• Language: croatian
• URN:NBN: urn:nbn:hr:163:730663
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-03-25 10:30:22