Fitoterapijski potencijal crnog papra (Piper nigrum L.)

professional thesis

• Author: Snježana Weltinger
• Mentor: Maja Bival Štefan (mentor)
• Committee member: Sanda Vladimir-Knežević (predsjednik povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Committee member: Zdenka Kalođera (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2022-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je pregled podataka dosadašnjih znanstvenih istraživanja o crnom papru (Piper nigrum L.).
Materijali i metode
Istraživanja u okviru ovoga specijalističkog rada su teorijskog karaktera, a uključuju pregled dostupne literature o dosadašnjim nekliničkim i kliničkim istraživanjima crnog papra. U pretraživanju su korištene dostupne elektronske bibliografske baze podataka Current Contents, ScienceDirect, Scopus, PubMed i Medline.
Rezultati
Usitnjeni plod crnog papra je širom svijeta poznat kao začin, a ima i višestoljetnu tradiciju medicinske primjene. Fitokemijskim istraživanjima ustanovljeno je da sadrži fitosterole, triterpene, fenolne spojeve, značajne koncentracije flavonoida (katehina, miricetina i kvercetina), karotenoida (luteina i β-karotena) minerala (kalij, kalcij, magnezij i fosfor) i vitamina C. Crni papar je snažan antioksidans te ima dokazano protupalno, imunomodulacijsko, antitumorsko, citotoksično, antimikrobno i analgetsko djelovanje. Farmakološki učinak zabilježen je kod liječenja astme, prehlade i kašlja, hipertenzije, pretilosti, bolesti probavnih organa, živčanog sustava i štitnjače. Dosadašnja klinička istraživanja ploda crnog papra ograničena su na povećanje terapijskog učinka lijekova i hranjivih tvari jer djeluje kao pojačivač njihove bioraspoloživosti.
Zaključci
Fitoterapijski potencijal crnog papra treba potvrditi daljnjim studijama jer dosadašnja klinička istraživanja ne pružaju dovoljnu razinu dokaza o terapijskoj učinkovitosti crnog papra.

Abstract (english)

Objectives
The aim of this specialist paper is to review the data of previous scientific research on black pepper (Piper nigrum L.).
Materials and methods
The research within this specialist paper is of a theoretical nature, and includes a review of the available literature on previous non-clinical and clinical research on black pepper. Available electronic bibliographic databases Current Contents, ScienceDirect, Scopus, PubMed and Medline were used in the search.
Results
Chopped black pepper is known worldwide as a spice, and has a centuries-old tradition of medical use. Phytochemical studies have shown that it contains phytosterols, triterpenes, phenolic compounds, significant concentrations of flavonoids (catechins, myricetin and quercetin), carotenoids (lutein and β-carotene) minerals (potassium, calcium, magnesium and phosphorus) and vitamin C. Black pepper is a strong. antioxidant and has proven anti-inflammatory, immunomodulatory, antitumor, cytotoxic, antimicrobial and analgesic effects. Pharmacological effect has been reported in the treatment of asthma, colds and coughs, hypertension, obesity, diseases of the digestive organs, nervous system and thyroid gland. Previous clinical trials of black pepper fruit have been limited to increasing the therapeutic effect of drugs and nutrients because it acts as an enhancer of their bioavailability.
Conclusions
The phytotherapeutic potential of black pepper should be confirmed by further studies because previous clinical studies do not provide a sufficient level of evidence on the therapeutic efficacy of black pepper.

• Keywords: crni papar; Piper nigrum L.; fitoterapija
• Keywords (english): black pepper; Piper nigrum L.; phytotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:851565
• Study programme: Title: Phytopharmacy with dietotherapy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom (sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-07-15 13:06:40