Medikacijske pogreške u pedijatrijskoj populaciji prijavljene Agenciji za lijekove i medicinske proizvode

master's thesis

• Title (english): Medication errors in pediatric population reported to Agency for Medicinal Products and Medical Devices
• Author: Lana Omrčen
• Mentor: Iva Mucalo (mentor)
• Mentor: Nikica Mirošević Skvrce (mentor)
• Committee member: Iva Mucalo (predsjednik povjerenstva)
• Committee member: Nikica Mirošević Skvrce (član povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2022-07-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Medikacijske pogreške su nenamjerne greške u propisivanju, čuvanju, izdavanju, pripremi i primjeni
lijekova u kliničkoj praksi koje su uzrokovale ili imaju potencijal uzrokovati nuspojave. Pedijatrijska
populacija je posebno osjetljiva na takve greške s obzirom na nedostatak prikladnih farmaceutskih
formulacija za djecu, složenosti doziranja istih te s obzirom na različitu farmakokinetiku, farmakodinamiku,
djelotvornost i sigurnosni profil u odnosu na odrasle pacijenata. Cilj ovog rada bio je analizirati medikacijske
pogreške za sve mlađe od 18 godina prijavljene Agenciji za lijekove i medicinske proizvode do 31. prosinca
2021. godine te podignuti svijest o neispravnom korištenju lijekova. Zaprimljene prijave medikacijskih
pogrešaka analizirane su prema vrsti prijavitelja, dobi i spolu pacijenata, raspodjeli suspektnih lijekova prema
ATK klasifikaciji, raspodjeli nuspojava prema djelatnim tvarima, ozbiljnosti prijave i njihovom kriteriju
ozbiljnosti te prijavljenim medikacijskim pogreškama i nuspojavama. Dobiveni rezultati ovog diplomskog
rada nadopunit će postojeće informacije i dokaze o medikacijskim pogreškama u pedijatrijskoj populaciji te
doprinijeti smanjenju učestalosti istih.

Abstract (english)

Medication error is unintended error in the prescribing, dispensing or administration of a medicinal
product in clinical practice that can cause or has potentional to cause harm. Pediatric population is
particularly vulnerable to such errors due to lack of suitable pharmaceutical formulations for children, the
complexity of dosing mediactions and different pharmacokinetics, pharmacodynamics, efficacy and safety
profile compared to adult patients. The aim of this study was to analyze medication errors for all under 18
years of age reported to the Agency for Medicinal Products and Medical Devices by 31 December 2021 and
to raise awareness about the misuse of medicines. The received reports of medication errors were analyzed
according to the type of applicant, age and sex of patients, distribution of suspected drugs according to ATK
classification, distribution of side effects according to suspected ingredient, seriousness of reports and their
seriousness criteria, and reported medication errors and side effects. The obtained results of this thesis
supplement the existing information and evidence of medication errors in the pediatric population and
contribute to reducing their frequency.

• Keywords: medikacijske pogreške; pedijatrijska populacija; djeca
• Keywords (english): medication errors; pediatrics; children
• Language: croatian
• URN:NBN: urn:nbn:hr:163:442084
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-07-26 13:43:02