Fitoterapijski pristup liječenju dislipidemije s ciljem prevencije kardiovaskularnih bolesti

master's thesis

• Title (english): Phytotherapy approach to the treatment of dyslipidemia with the aim of preventing cardiovascular diseases
• Author: Simona Melnjak
• Mentor: Maja Bival Štefan (mentor)
• Committee member: Maja Bival Štefan (predsjednik povjerenstva)
• Committee member: Biljana Blažeković (član povjerenstva)
• Committee member: Ana-Marija Domijan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2022-09-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Dislipidemija označava patološko stanje koje se manifestira kao neravnoteža koncentracije lipida,
odnosno povišene vrijednosti ukupnog i LDL-kolesterola te triglicerida i snižene vrijednosti HDLkolesterola.
Predstavlja jednog od glavnih čimbenika razvoja ateroskleroze i s njome povezanih
kardiovaskularnih bolesti. Poremećene koncentracije lipida čisti su primjer patološkog stanja
nastalog kako lošim prehrambenim navikama, tako i lošeg stila života. U svrhu pronalaska
potencijalnih fitopreparata za prevenciju i liječenje dislipidemije sa znanstveno potkrijepljenim
dokazima, pretraživane su baze podataka PubMed, Cochrane i ScienceDirect. Fitoterapeutici
proučavani u ovom diplomskom radu, crvena riža, češnjak, beta-glukani, artičoka, fitosteroli,
omega-3 masne kiseline, berberin, soja i polikozanol, kroz pregledana istraživanja pokazala su
pozitivne blagotvorne učinke na vrijednosti lipidnih parametara djelujući na više meta (inhibicija
sinteze, inhibicija apsorpcije i povećano izlučivanje kolesterola) uz minimalne nuspojave ukoliko se
primjenjuju sukladno preporukama. Osim na vrijednosti lipida, određeni fitoterapeutici pokazali su
pozitivne učinke na sam kardiovaskularni sustav. Trenutni podaci iz istraživanja ukazuju na
potencijalnu mogućnost primjene fitoterapeutika kao ključnog alata u poboljšanju koncentracija
lipida u plazmi kod ispitanika s blagom do umjerenom dislipidemijom uz niski kardiovaskularni
rizik, kao samostalni dodatak prehrani ili kao kombinacija sa standardnom farmakoterapijom te ih
je kao takve potrebno dodatno istraživati kroz dobro dizajnirana klinička ispitivanja.

Abstract (english)

Dyslipidaemia is a pathological condition that manifests itself as an imbalance in the concentration
of lipids. It includes increased values of total and LDL-cholesterol and triglycerides and decreased
values of HDL-cholesterol. Dyslipidaemia is one of the main factors in the appearance of
atherosclerosis and cardiovascular diseases. Imbalance od lipid concentrations is an example of a
pathological condition caused by both bad nutrition habits and bad lifestyle. In order to find potential
phytopreparations for the prevention and treatment of dyslipidemia with scientifically supported
evidence were searched PubMed, Cochrane and ScienceDirect. The phytotherapeutics studied in this
thesis, red rice, garlic, beta-glucans, artichoke, phytosterols, omega-3 fatty acids, berberine, soy and
policosanol, through reviewed studies have shown positive beneficial effects on concetrations of
lipid parameters by affecting on multiple targets (synthesis inhibition, inhibition of absorption and
increased excretion of cholesterol) with minimal side effects if they are used according to
recommendations. In addition to lipid values, certain phytotherapeutics have also shown positive
effects on the cardiovascular system. Current research results indicate the potential possibility of
using phytotherapeutics as a key in improving plasma lipid concentrations in patients with mild to
moderate dyslipidemia with low cardiovascular risk, used as an independent dietary supplement or
in combination with standard pharmacotherapy. Also, there is a need for new researches of potential
phytotherapeutics through well-designed clinical trials.

• Keywords: dislipidemija; hiperlipidemija; kolesterol; crvena riža; monakolin; češnjak; artičoka; beta glukani; fitosteroli; omega-3 masne kiseline; berberin; soja; polikozanol
• Keywords (english): dyslipidemia; hyperlipidemia; cholesterol; red yeast rice; monacolin; garlic; artichoke; beta-glucans; phytosterols; omega-3 fatty acids; berberine; soy; policosanol
• Language: croatian
• URN:NBN: urn:nbn:hr:163:835811
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2023-09-01
• Created on: 2022-09-02 12:03:50