Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože

professional thesis

• Author: Marjana Naletilić
• Mentor: Marijana Zovko Končić (mentor)
• Committee member: Sanda Vladimir-Knežević (predsjednik povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Committee member: Maja Lusina Kregar (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2022-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Poremećaji pigmentacije kože sve su češći estetski problem. Zlatni standard terapije je dugo
bio hidrokinon, ali se zbog njegovih nuspojava i dugoročne sigurnosti, intenzivno istražuju
biljni ekstrakti i sekundarni metaboliti koji se u njima nalaze. Cilj rada je pregled i
sistematizacija rezultata istraživanja biljnih ekstrakata i sekundarnih metabolita koji se koriste
u pripravcima za terapiju hiperpigmentacije kože te procjena učinkovitosti i opravdanosti
njihove primjene.
Materijal / Ispitanici i metode
Za potrebe pisanja pretražene su relevantne bibliografske baze podataka. Pretragom su
obuhvaćeni izvorni znanstveni radovi, prvenstveno kliničke studije, koje su ispitivale terapiju
hiperpigmentacije biljnim ekstraktima te biljnim sekundarnim metabolitima, a koje imaju
dostupne cjelovite tekstove ili iznimno sažetke. Odabir znanstvenih radova je bio ograničen na
one objavljene na engleskom jeziku. Radovi koji su odgovarali kriterijima bili su odabrani
neovisno o datumu njihove objave.
Rezultati
Studije uključene u ovaj rad pokazale su da su biljni ekstrakti učinkoviti u terapiji
hiperpigmetacije. U rad su uvrštene kliničke studije koje su ispitivale učinak aloe vere,
indijskog ogrozda, sjemenki grožđa, biljne vrste Klasea quinquefolia, orhideje Brassocattleya
marcella, peršina, primorskog bora, riže, sladića, štavelja i tratinčice, te sekundarnih metabolita
poput aloesina, kojične kiseline, glabridina i β-arbutina. Među navedenim biljnim ekstraktima
i sastavnicama najbolje su ispitani arbutin i kojična kiselina. Biljne opcije dovele su do
smanjenja veličine i intenziteta hiperpigmentacijskih mrlja, uz djelotvornost koja se može
usporediti s hidrokinonom, ali s manje nuspojava.
Zaključak
Biljni ekstrakti i sekundarni metaboliti obuhvaćeni ovim radom pokazali su značajan učinak u
tretmanu hiperpigmentacija. Unatoč tomu, potrebna su dodatna ispitivanja uz dugoročno
praćenje pacijenata i nakon prestanka upotrebe terapije, što će pridonijeti boljem uvidu u
učinkovitost i sigurnost njihove primjene.

Abstract (english)

Objectives
Skin pigmentation disorders are an increasingly common aesthetic problem. The gold standard
of therapy has long been hydroquinone, but due to its side effects and long-term safety, plant
extracts and secondary metabolites are intensively investigated. The aim of this work is to
review and systematize the results of research of plant extracts and secondary metabolites used
in products for skin hyperpigmentation and to assess the effectiveness and justification of their
application.
Material and Methods
For preparation of this work relevant bibliographic databases have been searched. The study
included original scientific papers, primarily clinical trials, which examined the therapy of
hyperpigmentation with herbal extracts and plant secondary metabolites. The studies with
available full texts or exceptionally summaries were included. The selection of scientific papers
was limited to those published in English. Papers that matched the criteria were selected
regardless of the date of their publication.
Results
Studies included in this work have demonstrated that herbal extracts are effective in therapy of
hyperpigmentation. Clinical studies done on Aloe vera, Indian gooseberry, grapevine seed,
plant species Klasea quinquefolia, orchid Brassocattleya marcella, parsley, maritime pine, rice,
licorice, amla and daisy, as well as secondary metabolites such as aloesin, kojic acid, glabridin
and β-arbutin have been included. Among the aforementioned plant extracts and metabolites
arbutin and kojic acid were included in the greatest number of studies. Herbal options have led
to a decrease in the size and intensity of hyperpigmentation spots, with efficacy comparable to
hydroquinon but with fewer side effects.
Conclusions
Herbal extracts and secondary metabolites have shown a significant effect in the treatment of
hyperpigmentation. However, additional trials with long-term monitoring even cessation of
therapy, are needed for better insight into their efficacy and safety.

• Keywords: koža; hiperpigmentacija kože; biljni ekstrakti; sekundarni metaboliti
• Keywords (english): skin; skin hyperpigmentation; herbal extracts; secondary metabolites
• Language: croatian
• URN:NBN: urn:nbn:hr:163:947493
• Study programme: Title: Dermopharmacy and cosmetology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-09-09 13:26:16